B9429
Anti-Bcl-xL antibody, Mouse monoclonal
~2 mg/mL, clone 2H12, purified from hybridoma cell culture
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About This Item
Conjugate:
unconjugated
Clone:
2H12, monoclonal
Application:
ARR, WB
Citations:
11
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
2H12, monoclonal
form
buffered aqueous solution
mol wt
antigen 27 kDa
species reactivity
rat, mouse, human
concentration
~2 mg/mL
technique(s)
microarray: suitable, western blot: 25-100 μg/mL using human epidermoid carcinoma A431 cell extract
isotype
IgG2a
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... BCL2L1(598)
mouse ... Bcl2l1(12048)
rat ... Bcl2l1(24888)
Immunogen
synthetic peptide corresponding to amino acids 3-14 shared by murine and human Bcl-xL, conjugated to KLH.
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
The antibody reacts with Bcl-xL protein, but not with Bcl-xS.
Physical form
Solution in phosphate buffered saline, pH 7.4 containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Peter F Vitiello et al.
Free radical biology & medicine, 44(3), 367-374 (2008-01-25)
The tumor suppressor protein p53 activates growth arrest and proapoptotic genes in response to DNA damage. It is known that negative feedback by p21(Cip1/Waf1/Sdi1) represses p53-dependent transactivation of PUMA. The current study investigates PUMA feedback on p53 during oxidative stress
A Notte et al.
Cell death & disease, 4, e638-e638 (2013-05-18)
Cancer cell resistance against chemotherapy is still a heavy burden to improve anticancer treatments. Autophagy activation and the development of hypoxic regions within the tumors are known to promote cancer cell resistance. Therefore, we sought to evaluate the role of
Vikash Kumar et al.
Oncotarget, 8(32), 53124-53136 (2017-09-09)
Ovarian cancer represents one of the most common malignancies among women with very high mortality rate worldwide. A-kinase anchor protein 4 (AKAP4), a unique cancer testis (CT) antigen has been shown to be associated with various malignant properties of cancer
Kenichiro Doi et al.
The Journal of biological chemistry, 287(13), 10224-10235 (2012-02-09)
The anti-apoptotic Bcl-2 family of proteins, including Bcl-2, Bcl-X(L) and Mcl-1, are well-validated drug targets for cancer treatment. Several small molecules have been designed to interfere with Bcl-2 and its fellow pro-survival family members. While ABT-737 and its orally active
Meng Shao et al.
Evidence-based complementary and alternative medicine : eCAM, 2018, 6049498-6049498 (2018-07-27)
Xihuang pill (XHP), a traditional Chinese herbal formula, has long been used as an effective agent against multiple tumors. The aim of this study is to evaluate the effects of XHP on the growth inhibition and apoptosis in glioblastoma U-87
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