Bone morphogenetic proteins (BMPs) are the members of the TGF-β superfamily and are identified as the critical factors for formation of bone and cartilage, hematopoietic cell formation and mesoderm patterning. Apart from this BMPs have immune regulatory functions. The cellular effects of BMPs are mediated by a heteromeric complex composed of type I and type II receptors. Bone Morphogenetic Protein Receptor 2 (BMP R2) is a 70-80kD protein that belongs to serine/threonine kinases family. BMPs bind to BMP R2 and then recruits the transducing type I receptor which in turn activate the Smad protein signaling pathway. Anti-Bone Morphogenetic Protein Receptor 2 (BMP R2) antibody can be used in western blotting (working concentration:- 0.1-0.2 μg/mL). Goat anti-BMP R2 antibody reacts specifically with recombinant human BMP-R2. The antibody exhibits 10% (approx.) cross-reactivity with recombinant mouse BMP-RIB using reducing conditions and less than 1% cross-reactivity with recombinant mouse BMP-RIA and recombinant human BMP-RIA.

recombinant human BMP R2 expressed in NSO cells.

Anti-Bone Morphogenetic Protein Receptor 2 (BMP R2) antibody may be used in indirect ELISA at a working antibody concentration of 0.5-1.0 μg/ml.

By immunoblotting (reducing conditions), the antibody shows 10% cross-reactivity with recombinant mouse BMP RIB and <1% cross-reactivity with recombinant human BMP RIA and recombinant mouse BMP RIA.

Lyophilized from solution in phosphate buffered saline containing 5% trehalose.

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