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Merck
CN

BM0001

Sigma-Aldrich

BMS-341400 methanesulfonate

≥98% (HPLC)

Synonym(s):

1-[9-[[(3-Chloro-4-methoxyphenyl)methyl]amino]-3-ethyl-3H-pyrazolo[4′,3′:5,6]pyrido[3,4-d]pyridazin-6-yl]-N-methyl-H-imidazole-4-carboxamide methanesulfonate (1:1), 1-[9-[[(3-Chloro-4-methoxyphenyl)methyl]amino]-3-ethyl-3Hpyrazolo[4′,3′:5,6]pyrido[3,4-d]pyridazin-6-yl]-4-methylimidazolecarboxamide methanesulfonate

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About This Item

Empirical Formula (Hill Notation):
C23H22ClN9O2 · CH4O3S
CAS Number:
296250-54-9
Molecular Weight:
588.04
UNSPSC Code:
12352200
PubChem Substance ID:
329774349

Key Documents

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

room temp

SMILES string

O=S(C)(O)=O.ClC1=CC(CNC2=C(C(C=NN3CC)=C3N=C4)C4=C(N5C=NC(C(NC)=O)=C5)N=N2)=CC=C1OC

InChI

1S/C23H22ClN9O2.CH4O3S/c1-4-33-21-15(10-29-33)19-14(9-27-21)22(32-11-17(28-12-32)23(34)25-2)31-30-20(19)26-8-13-5-6-18(35-3)16(24)7-13;1-5(2,3)4/h5-7,9-12H,4,8H2,1-3H3,(H,25,34)(H,26,30);1H3,(H,2,3,4)

InChI key

NTAGDQYHYAUFMS-UHFFFAOYSA-N

Biochem/physiol Actions

BMS-341400 is a selective and potent phosphodiesterase 5 (PDE 5) inhibitor.
BMS-341400 is a selective and potent phosphodiesterase 5 (PDE 5) inhibitor. BMS-341400 has an IC50 value of 0.3 nM and is 150-fold selective for PDE5 over PDE6 and over 10,000-fold selective for PDE5 over PDE1, PDE2, PDE3, and PDE4.

Features and Benefits

BMS-341400 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

Legal Information

Sold for research purposes only under agreement from BMS.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
125M4740V

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