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Merck
CN

BM0008

BMS-214662 hydrochloride

≥98% (HPLC)

Synonym(s):

(R)-2,3,4,5-Tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-Benzodiazepine-7-carbonitrile monohydrochloride, (R)-7-Cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine hydrochloride, BMS 214662

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About This Item

Empirical Formula (Hill Notation):
C25H23N5O2S2 · HCl
CAS Number:
195981-08-9
Molecular Weight:
526.07
PubChem Substance ID:
329774353
UNSPSC Code:
12352200

Key Documents

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InChI

1S/C25H23N5O2S2.ClH/c26-13-20-8-9-24-21(11-20)15-30(34(31,32)25-7-4-10-33-25)23(12-19-5-2-1-3-6-19)17-29(24)16-22-14-27-18-28-22;/h1-11,14,18,23H,12,15-17H2,(H,27,28);1H/t23-;/m1./s1

InChI key

LBPFLNDUCNNGPS-GNAFDRTKSA-N

SMILES string

O=S(N1CC(C=C(C#N)C=C2)=C2N(CC3=CN=CN3)C[C@H]1CC4=CC=CC=C4)(C5=CC=CS5)=O.[H]Cl

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

room temp

Quality Level

100

General description

BMS-214662 is a small molecule inhibitor containing an imidazole tetrahydro benzodiazepine and without thiol and peptide attached.

Biochem/physiol Actions

BMS-214662 is an orally available, potent and selective inhibitor of farnesyltransferase that reduces Ras prenylation in NF90-8 and ST88-14 sheath tumor (MPNST) cell lines. BMS-214662 induces apoptosis in cancer cell lines, and potently inhibits growth of human tumor xenografts.
BMS-214662 is an orally available, potent and selective inhibitor of farnesyltransferase.
It competes with other inhibitors for Ras protein substrate during inhibition of farnesyltransferase.

Features and Benefits

BMS-214662 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

Legal Information

Sold for research purposes only under agreement from BMS.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
076M4731V

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Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor.
Rose W C, et al.
Cancer Research, 61(20), 7507-7517 (2001)

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