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BM0010

Ifetroban sodium

≥98% (HPLC)

Synonym(s):

2-[[(1S,2R,3S,4R)-3-[4-[(Pentylamino)carbonyl]-2-oxazolyl]-7-oxabicyclo[2.2.1]hept-2-yl]methyl]-benzenepropanoic acid sodium salt, BMS 180291-02, BMS-180291 sodium, Sodium ifetroban

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About This Item

Empirical Formula (Hill Notation):
C25H31N2O5 · Na
CAS Number:
156715-37-6
Molecular Weight:
462.51
PubChem Substance ID:
329774354
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

room temp

SMILES string

[O-]C(CCC1=C(C[C@H]2[C@@H](O3)CC[C@@H]3[C@H]2C4=NC(C(NCCCCC)=O)=CO4)C=CC=C1)=O.[Na+]

InChI

1S/C25H32N2O5.Na/c1-2-3-6-13-26-24(30)19-15-31-25(27-19)23-18(20-10-11-21(23)32-20)14-17-8-5-4-7-16(17)9-12-22(28)29;/h4-5,7-8,15,18,20-21,23H,2-3,6,9-14H2,1H3,(H,26,30)(H,28,29);/q;+1/p-1/t18-,20-,21+,23-;/m0./s1

InChI key

WOHSQDNIXPEQAE-QBKVZTCDSA-M

Biochem/physiol Actions

Ifetroban (BMS-180291) is a potent and selective thromboxane receptor antagonist.
Ifetroban (BMS-180291) is a potent and selective thromboxane receptor antagonist. The IC50 for inhibition of arachadonate or U-46619-induced platelet aggregation in human plasma is 7 nM and 30 nM, respectively. Ifetroban inhibits platelet aggregation in African green monkey 100% at 3 mpk, and blocks the contractile effects of U-46619 and Ang II in rabbit renal afferent arterioles.

Features and Benefits

Ifetroban is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

Legal Information

Sold for research purposes only under agreement from BMS.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
076M4728V

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Global Trade Item Number

SKUGTIN
BM0010-5MG04061832784373

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