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Merck
CN

BM0018

BMS-906024

≥98% (HPLC)

Synonym(s):

(2R,3S)-N1-[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)-butanediamide

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About This Item

Empirical Formula (Hill Notation):
C26H26F6N4O3
CAS Number:
1401066-79-2
Molecular Weight:
556.50
NACRES:
NA.77
PubChem Substance ID:
329774361
UNSPSC Code:
12352200
MDL number:
MFCD24849414

Key Documents

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InChI

1S/C26H26F6N4O3/c1-36-19-10-6-5-9-18(19)20(15-7-3-2-4-8-15)34-22(24(36)39)35-23(38)17(12-14-26(30,31)32)16(21(33)37)11-13-25(27,28)29/h2-10,16-17,22H,11-14H2,1H3,(H2,33,37)(H,35,38)/t16-,17+,22+/m0/s1

SMILES string

O=C1N(C)C2=CC=CC=C2C(C3=CC=CC=C3)=N[C@@H]1NC([C@@H]([C@@H](C(N)=O)CCC(F)(F)F)CCC(F)(F)F)=O

InChI key

AYOUDDAETNMCBW-GSHUGGBRSA-N

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -100 to -110°, c = 1 in DMSO

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

room temp

Biochem/physiol Actions

BMS-906024 is a γ-secretase inhibitor and pan-Notch inhibitor with antineoplastic activity.
BMS-906024 is a γ-secretase inhibitor and pan-Notch inhibitor with antineoplastic activity. BMS-906024 is being studied as an anticancer agent and has shown good anti-leukemic activity in a case of early T-cell progenitor acute lymphoblastic leukemia.

Features and Benefits

BMS-906024 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

Legal Information

Sold for research purposes only under agreement from BMS.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000061001
0000040419
0000040420
0000032722
0000032723

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Charlotte Lübow et al.
Biochemical pharmacology, 175, 113864-113864 (2020-02-24)
Interleukin (IL)-1 signaling leads to production of pro-inflammatory mediators and is regulated by receptor endocytosis. Lysosomotropic drugs have been linked to increased pro-inflammatory responses under sterile inflammatory conditions but the underlying mechanisms have not been fully elucidated. Here, we report

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