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Merck
CN

BM0020

BMS-646786

≥98% (HPLC)

Synonym(s):

BPTU, N-[2-[2-(1,1-Dimethylethyl)phenoxy]-3-pyridinyl]-N′-[4-(trifluoromethoxy)phenyl]-urea

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About This Item

Empirical Formula (Hill Notation):
C23H22F3N3O3
CAS Number:
870544-59-5
Molecular Weight:
445.43
NACRES:
NA.77
PubChem Substance ID:
329774363
UNSPSC Code:
12352200
MDL number:
MFCD28386231

Key Documents

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InChI key

AHFLGPTXSIRAQK-UHFFFAOYSA-N

SMILES string

O=C(NC1=CC=C(OC(F)(F)F)C=C1)NC2=C(OC3=CC=CC=C3C(C)(C)C)N=CC=C2

InChI

1S/C23H22F3N3O3/c1-22(2,3)17-7-4-5-9-19(17)31-20-18(8-6-14-27-20)29-21(30)28-15-10-12-16(13-11-15)32-23(24,25)26/h4-14H,1-3H3,(H2,28,29,30)

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

BMS-646786 is a potent and specific inhibitor of P2Y1 purinergic receptor that inhibits ADP-mediated platelet aggregation in human blood samples. BMS-646786 significantly reduces thrombus weight in a rat arterial thrombosis model with a limited effect on bleeding.
BMS-646786 is a potent and specific inhibitor of P2Y1 purinergic receptor.

Features and Benefits

BMS-646786 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

Legal Information

Sold for research purposes only under agreement from BMS.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
076M4735V

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Chiao-Hsuan Chao et al.
PLoS pathogens, 15(4), e1007625-e1007625 (2019-04-23)
Dengue virus (DENV) infection, the most common mosquito-transmitted viral infection, can cause a range of diseases from self-limiting dengue fever to life-threatening dengue hemorrhagic fever and shock syndrome. Thrombocytopenia is a major characteristic observed in both mild and severe dengue

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