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Merck
CN

BM0030

BMS-248360

≥98% (HPLC)

Synonym(s):

4′-[(2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-2′-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl][1,1′-biphenyl]-2-sulfonamide

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About This Item

Empirical Formula (Hill Notation):
C36H45N5O5S
CAS Number:
254737-87-6
Molecular Weight:
659.84
UNSPSC Code:
12352200
MDL number:
MFCD09027363

Key Documents

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InChI key

NBDFXMDYBLSGLX-UHFFFAOYSA-N

InChI

1S/C36H45N5O5S/c1-6-7-14-31-37-36(17-10-11-18-36)34(43)41(31)22-26-15-16-28(27(21-26)23-40-20-19-35(4,5)33(40)42)29-12-8-9-13-30(29)47(44,45)39-32-24(2)25(3)38-46-32/h8-9,12-13,15-16,21,39H,6-7,10-11,14,17-20,22-23H2,1-5H3

SMILES string

CCCCC(N1CC2=CC=C(C3=CC=CC=C3S(=O)(NC4=C(C)C(C)=NO4)=O)C(CN5CCC(C)(C)C5=O)=C2)=NC6(CCCC6)C1=O

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

BMS-248360 is an orally active dual antagonist of angiotensin II subtype 1 (AT1) and endothelin subtype A (ETA) receptors.
BMS-248360 is an orally active dual antagonist of angiotensin II subtype 1 (AT1) and endothelin subtype A (ETA) receptors. BMS-248360 exhibited a broader spectrum of antihypertensive activity when compared to individual AT1 or ETA receptor antagonists.

Features and Benefits

BMS-248360 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

Legal Information

Sold for research purposes only under agreement from BMS.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
126M4741V

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