C0206
R(+)-SCH-23390 hydrochloride
Synonym(s):
R(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C17H18ClNO · HCl
CAS Number:
Molecular Weight:
324.24
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
Cl[H].CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c3ccccc3
InChI
1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1
InChI key
OYCAEWMSOPMASE-XFULWGLBSA-N
Biochem/physiol Actions
Selective D1 dopamine receptor antagonist
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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K M O'Boyle et al.
Journal of neurochemistry, 48(4), 1039-1042 (1987-04-01)
A series of 1-phenyl-1H-3-benzazepine analogues were assessed for enantiomeric and structure-affinity relationships at human putamen D-1 dopamine receptors labelled with [3H]SCH 23390. Substitution at the 7-position of both 3-H and 3-methyl benzazepine molecules critically affected affinity for these receptors over
Steven Tran et al.
Psychopharmacology, 232(20), 3709-3718 (2015-07-27)
The zebrafish has become an increasingly popular animal model for investigating ethanol's actions in the brain and its effects on behavior. Acute exposure to ethanol in zebrafish has been shown to induce a dose-dependent increase of locomotor activity, to reduce
Katherine E Savell et al.
Science advances, 6(26), eaba4221-eaba4221 (2020-07-09)
Drugs of abuse elevate dopamine levels in the nucleus accumbens (NAc) and alter transcriptional programs believed to promote long-lasting synaptic and behavioral adaptations. Here, we leveraged single-nucleus RNA-sequencing to generate a comprehensive molecular atlas of cell subtypes in the NAc