C0228
Anti-phospho-Cdc2 (Cdk1) (pTyr15) antibody produced in rabbit
affinity isolated antibody, buffered aqueous glycerol solution
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About This Item
UNSPSC Code:
12352203
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IP, WB CL
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
mouse, rat, human
technique(s)
immunoprecipitation (IP): 1:100, western blot (chemiluminescent): 1:1,000 using extract from hydroxyurea treated Saos cells
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr15)
Gene Information
human ... CDC2(983)
mouse ... Cdc2a(12534)
rat ... Cdc2(54237)
Immunogen
synthetic phosphopeptide corresponding to residues around Tyr15 of human Cdc2.
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
The antibody detects phosphorylated tyrosine on Cdc2 and Cdk1. It does not react with non-phosphorylated Cdc2, Cdk4, Cdk6, or Cdk7.
Physical form
Solution in 10 mM sodium HEPES, pH 7.5, containing 0.15 M sodium chloride, 100 μg/ml bovine serum albumin, and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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H Kawasaki et al.
The EMBO journal, 20(16), 4618-4627 (2001-08-14)
M-phase promoting factor is a complex of cdc2 and cyclin B that is regulated positively by cdc25 phosphatase and negatively by wee1 kinase. We isolated the wee1 gene promoter and found that it contains one AP-1 binding motif and is
Dong Xiao et al.
Environmental and molecular mutagenesis, 50(3), 201-212 (2008-09-19)
Garlic-derived organosulfur compounds (OSCs) are highly effective in affording protection against chemically induced pulmonary carcinogenesis in animal models. We now demonstrate that garlic constituent diallyl trisulfide (DATS) suppresses viability of cultured human lung cancer cell lines H358 (anon-small cell lung
Weijun Liu et al.
Carcinogenesis, 29(2), 263-272 (2008-01-05)
As a critical ubiquitin ligase, the anaphase-promoting complex/cyclosome (APC/C) governs cell cycle progression, signaling modulation and the pathogenesis of some human diseases. Recent studies implicate APC in maintaining genomic integrity, but the mechanism by which it plays such a role