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Merck
CN

C0290

Clopamide

Synonym(s):

4-Chloro-N-(2,6-dimethylpiperidinyl)-3-sulfamoylbenzamide

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About This Item

Empirical Formula (Hill Notation):
C14H20ClN3O3S
CAS Number:
636-54-4
Molecular Weight:
345.84
UNSPSC Code:
41116107
PubChem Substance ID:
24892248
EC Number:
211-261-7
MDL number:
MFCD00941495

Key Documents

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InChI key

LBXHRAWDUMTPSE-AOOOYVTPSA-N

InChI

1S/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21)/t9-,10+

SMILES string

C[C@@H]1CCC[C@H](C)N1NC(=O)c2ccc(Cl)c(c2)S(N)(=O)=O

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

format

neat

storage temp.

2-8°C

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
018F0915

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S Wanwimolruk et al.
Journal of chromatography, 572(1-2), 227-238 (1991-12-06)
A sensitive high-performance liquid chromatographic (HPLC) method for the quantitation of famotidine in human plasma is described. Clopamide was used as the internal standard. Plasma samples were extracted with diethyl ether to eliminate endogenous interferences. Plasma samples were then extracted
C Lengyel et al.
Orvosi hetilap, 138(16), 1003-1006 (1997-04-20)
A case of erythromycin-induced acquired long QT syndrome and "torsades de pointes" ventricular tachycardia is reported. The peculiar ventricular tachyarrhythmia was evoked by orally administered erythromycin (1.5 g/die) in the presence of diuretic (clopamide)-induced hypokalaemia. The pause-dependent "torsades de pointes"
W Stüber et al.
Journal of pharmaceutical sciences, 78(8), 679-682 (1989-08-01)
A gas-liquid chromatography-mass spectroscopy (GLC-MS) method for the determination of clopamide (1) in human plasma was developed to evaluate the pharmacokinetics and bioavailability of 1 in humans. The method is specific, sensitive, and rapid and allows routine analysis as required
L Landriani et al.
Farmaco (Societa chimica italiana : 1989), 44(11), 1059-1068 (1989-11-01)
A series of N-(4-chloro-3-sulfamoylbenzamido)-1,2,3,4-tetrahydroquinoline++ + (IV-1) and isoquinoline (IV-2) have been synthesized and their diuretic and antihypertensive activities evaluated. While none of the test compounds was found to be provided with antihypertensive properties, most of them displayed a diuretic activity
B Krönig et al.
Hypertension (Dallas, Tex. : 1979), 29(2), 651-658 (1997-02-01)
Low-dose combination therapy has been proposed as a rational first-line approach to hypertension treatment. We compared the efficacy and tolerability of the fixed combination of reserpine (0.1 mg) plus the thiazide clopamid (5 mg) with its single components and the
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