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Merck
CN

C0297

Monoclonal Anti-Caldesmon antibody produced in mouse

clone C21, ascites fluid

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About This Item

UNSPSC Code:
12352203
MDL number:
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biological source

mouse

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

C21, monoclonal

contains

15 mM sodium azide

species reactivity

mammals

technique(s)

indirect ELISA: 1:2,500, western blot: suitable

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... CALD1(800)
mouse ... Cald1(109624)
rat ... Cald1(25687)

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Immunogen

chicken caldesmon

Biochem/physiol Actions

The antibody is directed against an epitope near the carboxy-terminus, Ca2+/calmodulin and F-actin binding site of caldesmon. Using ELISA, the antibody is able to inhibit caldesmon binding to Ca2+/calmodulin and F-actin. By immunoblotting, the antibody shows broad species reactivity to non-muscle caldesmon of mammalian cells.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Julie L Boerner et al.
Oncogene, 22(43), 6679-6689 (2003-10-14)
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J J Lin et al.
Hybridoma, 7(3), 273-288 (1988-06-01)
Monoclonal antibodies, C2, C9, C18, C21 and C23, against chicken gizzard caldesmon have been prepared and characterized. These antibodies reacted with gizzard caldesmon (150 KDa) by enzyme-linked immunosorbent assay and protein immunoblotting. Immunofluorescence microscopy with these antibodies on cultured gizzard
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The Journal of biological chemistry, 290(11), 7067-7086 (2015-01-18)
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M J McManus et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(21), 11351-11356 (1997-10-23)
The avian erythroblastosis viral oncogene (v-erbB) encodes a receptor tyrosine kinase that possesses sarcomagenic and leukemogenic potential. We have expressed transforming and nontransforming mutants of v-erbB in fibroblasts to detect transformation-associated signal transduction events. Coimmunoprecipitation and affinity chromatography have been

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