C0331
6-Chloromelatonin
Synonym(s):
N-Acetyl-6-chloro-5-methoxytryptamine
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C13H15ClN2O2
CAS Number:
Molecular Weight:
266.72
UNSPSC Code:
12352103
MDL number:
SMILES string
COc1cc2c(CCNC(C)=O)c[nH]c2cc1Cl
solubility
alcohol: soluble
storage temp.
2-8°C
Gene Information
human ... MTNR1A(4543), MTNR1B(4544)
Biochem/physiol Actions
Melatonin agonist active at nanomolar concentrations; binds more strongly than melatonin at the receptor. Also has binding sites outside the CNS, i.e., at the adrenal gland. Possesses antiproliferative activity.
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
S P Persengiev
Life sciences, 51(9), 647-651 (1992-01-01)
Specific binding sites for 2-[125I] iodomelatonin, a selective radiolabeled melatonin receptor ligand, were detected and characterized in rat adrenal membranes. Saturation studies demonstrated that 2-[125I]iodomelatonin binds to a single class of sites with an affinity constant (Kd) of 541 pM
S W Ying et al.
European journal of pharmacology, 246(2), 89-96 (1993-07-15)
In order to explore the potential oncostatic properties of the pineal hormone, melatonin, we have investigated its binding characteristics and functional effects in a human malignant melanoma (M-6) cell line. Binding studies in M-6 membranes showed the coexistence of 2-[125I]iodomelatonin
C Browning et al.
British journal of pharmacology, 129(5), 877-886 (2000-03-01)
We have pharmacologically characterized recombinant human mt(1) and MT(2) receptors, stably expressed in Chinese hamster ovary cells (CHO-mt(1) and CHO-MT(2)), by measurement of [(3)H]-melatonin binding and forskolin-stimulated cyclic AMP (cAMP) production. [3H]-melatonin bound to mt(1) and MT(2) receptors with pK(D)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service