C0496
CRT0044876
≥98% (HPLC)
Synonym(s):
7-Nitro-1H-indole-2-carboxylic acid, 7-Nitroindole-2carboxylic acid, NSC 69877
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About This Item
Empirical Formula (Hill Notation):
C9H6N2O4
CAS Number:
Molecular Weight:
206.15
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
230-154-6
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
solubility
DMSO: >20 mg/mL
storage temp.
room temp
SMILES string
OC(=O)c1cc2cccc([N+]([O-])=O)c2[nH]1
InChI
1S/C9H6N2O4/c12-9(13)6-4-5-2-1-3-7(11(14)15)8(5)10-6/h1-4,10H,(H,12,13)
InChI key
BIUCOFQROHIAEO-UHFFFAOYSA-N
Biochem/physiol Actions
CRT0044876 targets the APE1 active site and inhibits 3′-phosphodiesterase and 3′-phosphatase activities.
CRT0044876 targets the apurinic endonuclease (APE1) active site and inhibits its 3′-phosphodiesterase and 3′-phosphatase activities—essential steps in excision repair—with minimal effects on endonuclease IV, BamH1 restriction endonuclease, or topoisomerase I even at concentrations as high as 100 μM. At non-cytotoxic concentrations, CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds, with accumulation of apurinic sites.
Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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