C0557
Bis(2-carboxyethylgermanium(IV) sesquioxide)
Synonym(s):
GE 132
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About This Item
Linear Formula:
O[Ge(=O)CH2CH2CO2H]2
CAS Number:
Molecular Weight:
339.42
UNSPSC Code:
12352103
PubChem Substance ID:
EC Number:
235-800-0
MDL number:
InChI key
XEABSBMNTNXEJM-UHFFFAOYSA-N
InChI
1S/C6H10Ge2O7/c9-5(10)1-3-7(13)15-8(14)4-2-6(11)12/h1-4H2,(H,9,10)(H,11,12)
SMILES string
OC(=O)CC[Ge](=O)O[Ge](=O)CCC(O)=O
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Biochem/physiol Actions
An organic germanium-containing compound that induces natural killer T cells in mice. These cells secrete interferon-γ. IFN-γ levels were elevated 20 hours after administration of 300 mg/kg.
Storage Class
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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K Ikemoto et al.
Experientia, 52(2), 159-166 (1996-02-15)
2-Carboxyethylgermanium sesquioxide (Ge-132), a synthesized organogermanium compound with immunomodulating activities, was shown to be an inducer of anti-suppressor T cells in normal mice. The suppressor cell activity of T6S cells, a clone of burn-induced CD8+ IL-4-producing suppressor T cells, was
H Aso et al.
Microbiology and immunology, 29(1), 65-74 (1985-01-01)
After oral administration of an organic germanium compound, Ge-132 (300 mg/kg), a significant level of interferon (IFN) activity was detected in the sera of mice at 20 hr and it reached a maximum of 320 U/ml at 24 hr. This
H Kobayashi et al.
Immunopharmacology and immunotoxicology, 14(4), 841-864 (1992-01-01)
The effect of 2-carboxyethylgermanium sesquioxide (Ge-132) on the generation of splenic suppressor macrophages (S-M phi) in C3H/He mice (H-2k) immunized with allogeneic spleen cells from C57Bl/6 mice (H-2b) was investigated. We have previously demonstrated that S-M phi expressing I-J antigen
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