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Merck
CN

C0617

Anti-CLAN Protein (CARD12) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Caspase Recruitment Domain Protein 12, Anti-ICE-Protease Activating Factor (IPAF)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD08705448
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
2

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~116 kDa (CLAN-A), antigen ~40 kDa (CLAN-B)

species reactivity

human

technique(s)

western blot: 1:500-1:1,000 using lung lysates

UniProt accession no.

Q9NPP4

shipped in

dry ice

storage temp.

−20°C

Quality Level

200

Gene Information

human ... NLRC4(58484)

General description

NLR family CARD domain-containing protein 4 is a protein encoded by NLRC4 gene in humans. NLRC4 is also known as CLAN, IPAF, CLAN1, CLANA, CLANB, CLANC, CLAND, CARD12 and CLR2. It is a member of the Ced4/ Apaf-1 family.

Immunogen

peptide corresponding to the N-terminus of the human CLAN protein, both A and B isoforms.

Application

Anti-CLAN Protein (CARD12) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:1,000 using human lung lysates.

Biochem/physiol Actions

CLAN (CARD12) induces apoptosis and plays a critical role in NF-κB signaling pathways. CARD12 plays an important role during activation of caspase-1 and is dependent on the nucleotide-binding site. It prevents motor-neuron apoptosis induced by a variety of signals.

Physical form

Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
075K1524

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B J Geddes et al.
Biochemical and biophysical research communications, 284(1), 77-82 (2001-05-26)
The CED4/Apaf-1 family of proteins functions as critical regulators of apoptosis and NF-kappaB signaling pathways. A novel human member of this family, called CARD12, was identified that induces apoptosis when expressed in cells. CARD12 is most similar in structure to
Chafen Lu et al.
Biochemical and biophysical research communications, 331(4), 1114-1119 (2005-05-11)
CARD12 (Ipaf/Clan) is an important regulator of caspase-1 activation. It belongs to the family of the nucleotide-binding site and leucine-rich repeat (NBS-LRR) proteins. The NBS domain of the NBS-LRR proteins contains putative ATP/GTPase-specific P-loop and Mg2+-binding site motifs. However, the

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