C0845
6Ckine from mouse
≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym(s):
Exodus-2, SLC
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About This Item
Biological source:
mouse
Recombinant:
expressed in E. coli
Assay:
≥98% (HPLC), ≥98% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
16-17 kDa by SDS-PAGE
Impurities:
endotoxin, tested
biological source
mouse
recombinant
expressed in E. coli
assay
≥98% (HPLC), ≥98% (SDS-PAGE)
form
lyophilized powder
mol wt
16-17 kDa by SDS-PAGE
packaging
pkg of 25 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Ccl21a(18829), Ccl21b(20298)
Biochem/physiol Actions
The expression of mouse 6Ckine has been detected at high levels in the spleen and lung. Recombinant mouse 6Ckine chemotattracts in vitro thymocytes and activated T-cells.
Physical form
Lyophilized with no additives.
Analysis Note
The biological activity is measured by its ability to chemoattract total murine T cell population.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Alexei Y Savinov et al.
The Journal of experimental medicine, 197(5), 643-656 (2003-03-05)
Activated insulin-specific CD8(+) T cells (IS-CD8(+) cells) home to the pancreas, destroy beta cells, and cause rapid diabetes upon transfer into diabetes-prone NOD mice. Surprisingly, they also cause diabetes in mouse strains that are free of preexistent inflammation. Thus, we
Long Chen et al.
Molecular cancer, 12(1), 153-153 (2013-12-07)
Secondary lymphoid tissue chemokine (SLC) is a key CC chemokine for chemotaxis of immune cells and has been an attractive candidate for anti-tumor treatments. However, among the immune cells recruited by SLC to tumors, the CD25+ Foxp3+ regulatory T cells
Rilun Li et al.
Molecular biology reports, 40(10), 5615-5623 (2013-10-01)
To explore the anti-tumor effect and immune mechanism mediated by a new recombinant adeno-associated virus (rAAV) encoding secondary lymphoid tissue chemokine (SLC) mature peptide gene. AAV Helper-Free system was used for rAAV-SLC package. The anti-tumor effect of SLC was detected
W Weninger et al.
The Journal of experimental medicine, 194(7), 953-966 (2001-10-03)
It has been proposed that two different antigen-experienced T cell subsets may be distinguishable by their preferential ability to home to lymphoid organs (central memory cells) or nonlymphoid tissues (effector memory/effector cells). We have shown recently that murine antigen-primed CD8(+)
Sherven Sharma et al.
Molecular cancer, 2, 22-22 (2003-05-13)
SLC/CCL21, normally expressed in high endothelial venules and in T cell zones of spleen and lymph nodes, strongly attracts T cells and dendritic cells (DC). We have previously shown that SLC/CCL21-mediated anti-tumor responses are accompanied by significant induction of IFNgamma
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