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C111000

DMT-dC(bz) Phosphoramidite

Name: DMT-dC(bz) Phosphoramidite
Brand: SIGMA

Synonym(s):

Cytidine, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite], DMT-dC(bz) amidite, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxycytidine, 3′-[2-cyanoethyl N,N-?bis(1-methylethyl)phosphoramidite], N4-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxycytidine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]

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About This Item

Empirical Formula (Hill Notation):

C₄₆H₅₂N₅O₈P

CAS Number:

102212-98-6

Molecular Weight:

833.91

NACRES:

NA.51

PubChem Substance ID:

329774845

UNSPSC Code:

41116107

MDL number:

MFCD00036315

Assay:

≥99% (³¹P-NMR), ≥99.0% (reversed phase HPLC)

Biological source:

non-animal source (no BSE/TSE risk)

Form:

powder or granules

Storage temp.:

2-8°C

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Properties

biological source

non-animal source (no BSE/TSE risk)

Quality Level

200

type

for DNA synthesis

product line

Proligo Reagents

assay

≥99% (³¹P-NMR), ≥99.0% (reversed phase HPLC)

form

powder or granules

technique(s)

oligo synthesis: suitable

impurities

≤0.3 wt. % water content (Karl Fischer)

color

white to off-white

λ

conforms (UV/VIS Identity)

nucleoside profile

base: deoxycytidine
base protecting group: benzoyl
2' protecting group: none
5' protecting group: DMT
deprotection: standard

storage temp.

2-8°C

SMILES string

COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)N3C=CC(NC(=O)c4ccccc4)=NC3=O)(c5ccccc5)c6ccc(OC)cc6

InChI

1S/C46H52N5O8P/c1-32(2)51(33(3)4)60(57-29-13-27-47)59-40-30-43(50-28-26-42(49-45(50)53)48-44(52)34-14-9-7-10-15-34)58-41(40)31-56-46(35-16-11-8-12-17-35,36-18-22-38(54-5)23-19-36)37-20-24-39(55-6)25-21-37/h7-12,14-26,28,32-33,40-41,43H,13,29-31H2,1-6H3,(H,48,49,52,53)/t40-,41+,43+,60?/m0/s1

InChI key

PGTNFMKLGRFZDX-SALLYJDFSA-N

Description

General description

DMT-dC(bz) Phosphoramidite belongs to the group of DNA Phosphoramidites.Its key features include:

Exocyclic amine functions are protected by a benzoyl group (dA(bz) anddC(bz)) or isobutyryl group (dG(ib))
Recommended cleavage and deprotection conditions are 8 hours at 55 °Cor 24 hours at room temperature using concentrated ammonia solution, for standard base-protected oligonucleotides
The high coupling efficiency of Proligo′s DNA phosphoramidites leads to high-yield and high-quality oligonucleotides

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Global Trade Item Number

SKU	GTIN
C111000-1KG	04061832946757
C111000-6X10G	04061832946788
C111000-6X20G	04061832946795
C111000-100G	04061832946740
C111000-20X40G	04061832025209
C111000-500G	04061832946771
C111000-4X30G	04061832946764
C111000-GIR	04061826590416
C111000-C	04061826703021
C111000-AVC	04061826590409