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C1115

Chrysamine G

Name: Chrysamine G
Brand: SIGMA

≥95% (HPLC), ß-amyloid aggregates probe, solid

Synonym(s):

4,4′-Bis(3-carboxy-4-hydroxyphenylazo)biphenyl disodium salt

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₁₆N₄Na₂O₆

CAS Number:

6472-91-9

Molecular Weight:

526.41

UNSPSC Code:

12352116

PubChem Substance ID:

24724433

NACRES:

NA.77

MDL number:

MFCD00045823

Assay:

≥95% (HPLC)

Form:

solid

Quality level:

100

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Product Name

Chrysamine G, ≥95% (HPLC), solid

Quality Level

100

assay

≥95% (HPLC)

form

solid

color

, orange to red to very dark brown

solubility

DMSO: ~4 mg/mL

storage temp.

−20°C

SMILES string

[Na+].[Na+].Oc1ccc(cc1C([O-])=O)N=Nc2ccc(cc2)-c3ccc(cc3)N=Nc4ccc(O)c(c4)C([O-])=O

InChI

1S/C26H18N4O6.2Na/c31-23-11-9-19(13-21(23)25(33)34)29-27-17-5-1-15(2-6-17)16-3-7-18(8-4-16)28-30-20-10-12-24(32)22(14-20)26(35)36;;/h1-14,31-32H,(H,33,34)(H,35,36);;/q;2*+1/p-2

InChI key

AZOPGDOIOXKJRA-UHFFFAOYSA-L

Related Categories

Bioactive Small Molecules

General description

Chrysamine G is a carboxylic acid derivative of Congo red.

Biochem/physiol Actions

Chrysamine G can penetrate the blood-brain barrier. It is useful in quantifying cerebral amyloid β (Aβ) deposition in Alzheimer′s disease (AD) pathological studies.

New probe for β-amyloid aggregates.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000425667

0000427530

0000247047

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Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy.

V Heiser et al.

Proceedings of the National Academy of Sciences of the United States of America, 97(12), 6739-6744 (2000-06-01)

The accumulation of insoluble protein aggregates in intra and perinuclear inclusions is a hallmark of Huntington's disease (HD) and related glutamine-repeat disorders. A central question is whether protein aggregation plays a direct role in the pathogenesis of these neurodegenerative diseases.

Chrysamine-G binding to Alzheimer and control brain: autopsy study of a new amyloid probe.

W E Klunk et al.

Neurobiology of aging, 16(4), 541-548 (1995-07-01)

Chrysamine-G (CG) is a carboxylic acid analogue of Congo red, a histologic dye which stains amyloid. CG binds to the beta-amyloid protein of Alzheimer's disease (AD) in vitro and partitions into the brain of normal mice. In this study, we

99mTc-MAMA-chrysamine G, a probe for beta-amyloid protein of Alzheimer's disease.

N A Dezutter et al.

European journal of nuclear medicine, 26(11), 1392-1399 (1999-11-07)

Chrysamine G (CG), an analogue of Congo red, is known to bind in vitro to the beta-amyloid protein (Abeta 10-43) and to homogenates of several regions of the brain of Alzheimer's disease (AD) patients. We synthesised a conjugate of 2-(acetamido)-CG

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.

Fusheng Yang et al.

The Journal of biological chemistry, 280(7), 5892-5901 (2004-12-14)

Alzheimer's disease (AD) involves amyloid beta (Abeta) accumulation, oxidative damage, and inflammation, and risk is reduced with increased antioxidant and anti-inflammatory consumption. The phenolic yellow curry pigment curcumin has potent anti-inflammatory and antioxidant activities and can suppress oxidative damage, inflammation

In vitro drug treatments reduce the deleterious effects of aggregates containing polyAla expanded PHOX2B proteins.

Eleonora Di Zanni et al.

Neurobiology of disease, 45(1), 508-518 (2011-10-04)

Heterozygous in frame duplications of the PHOX2B gene, leading to polyalanine (polyAla) expansions ranging from +5 to +13 residues of a 20-alanine stretch, have been identified in the vast majority of patients affected with Congenital Central Hypoventilation Syndrome (CCHS), a

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Global Trade Item Number

SKU	GTIN
C1115-10MG	04061832980867
C1115-25MG	04061832980874
NISTC1115	04061834190714

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