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Merck
CN

C1115

Chrysamine G

≥95% (HPLC), ß-amyloid aggregates probe, solid

Synonym(s):

4,4′-Bis(3-carboxy-4-hydroxyphenylazo)biphenyl disodium salt

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About This Item

Empirical Formula (Hill Notation):
C26H16N4Na2O6
CAS Number:
6472-91-9
Molecular Weight:
526.41
UNSPSC Code:
12352116
PubChem Substance ID:
24724433
NACRES:
NA.77
MDL number:
MFCD00045823
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
100

Key Documents

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Product Name

Chrysamine G, ≥95% (HPLC), solid

SMILES string

[Na+].[Na+].Oc1ccc(cc1C([O-])=O)N=Nc2ccc(cc2)-c3ccc(cc3)N=Nc4ccc(O)c(c4)C([O-])=O

InChI key

AZOPGDOIOXKJRA-UHFFFAOYSA-L

InChI

1S/C26H18N4O6.2Na/c31-23-11-9-19(13-21(23)25(33)34)29-27-17-5-1-15(2-6-17)16-3-7-18(8-4-16)28-30-20-10-12-24(32)22(14-20)26(35)36;;/h1-14,31-32H,(H,33,34)(H,35,36);;/q;2*+1/p-2

assay

≥95% (HPLC)

form

solid

color

, orange to red to very dark brown

solubility

DMSO: ~4 mg/mL

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Chrysamine G can penetrate the blood-brain barrier. It is useful in quantifying cerebral amyloid β (Aβ) deposition in Alzheimer′s disease (AD) pathological studies.
New probe for ß-amyloid aggregates.

General description

Chrysamine G is a carboxylic acid derivative of Congo red.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000427530
0000427530
0000247047
0000247047
0000187029

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V Heiser et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(12), 6739-6744 (2000-06-01)
The accumulation of insoluble protein aggregates in intra and perinuclear inclusions is a hallmark of Huntington's disease (HD) and related glutamine-repeat disorders. A central question is whether protein aggregation plays a direct role in the pathogenesis of these neurodegenerative diseases.
Kazuhiro Ishii et al.
Neuroscience letters, 333(1), 5-8 (2002-10-29)
The neurotoxicity of amyloid beta (Abeta) is widely believed to play a seminal role in neurodegeneration in Alzheimer's disease. We examined the effect of Chrysamine G (CG) on such neurotoxicity using the specific measurement of surviving neurons. CG was found
Virginia M-Y Lee
Neurobiology of aging, 23(6), 1039-1042 (2002-12-10)
Extracellular senile plaques (SPs) are hallmark brain lesions of sporadic Alzheimer's disease (AD) and the likely consequence of genetic mutations that cause familial AD by increasing production of amyloidogenic amyloid-beta (Abeta). Although Abeta vaccines and inhibitors of amyloidogenic secretases are
W E Klunk et al.
Neurobiology of aging, 15(6), 691-698 (1994-11-01)
This study describes the synthesis and in vitro testing of small molecule probes that may eventually prove useful as markers of amyloid deposition in living patients. The prototype agent, Chrysamine G (CG), is a derivative of Congo red. CG binds
D L Smith et al.
Neurobiology of disease, 8(6), 1017-1026 (2001-12-14)
Huntington's disease (HD) is a late onset neurodegenerative disorder caused by a CAG/polyglutamine (polyQ) repeat expansion. PolyQ aggregates can be detected in the nuclei and processes of neurons in HD patients and mouse models prior to the onset of symptoms.
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