C1119
Caroverine hydrochloride
≥98% (HPLC), solid
Synonym(s):
1-[2-(Diethylamino)ethyl]-3-[(4-methoxyphenyl)methyl]-2(1H)-quinoxalinone monohydrochloride
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About This Item
Empirical Formula (Hill Notation):
C22H28ClN3O2
CAS Number:
Molecular Weight:
401.93
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Quality Level
Assay
≥98% (HPLC)
form
solid
solubility
DMSO: >10 mg/mL
H2O: insoluble
storage temp.
2-8°C
SMILES string
Cl.CCN(CC)CCN1C(=O)C(Cc2ccc(OC)cc2)=Nc3ccccc13
InChI
1S/C22H27N3O2.ClH/c1-4-24(5-2)14-15-25-21-9-7-6-8-19(21)23-20(22(25)26)16-17-10-12-18(27-3)13-11-17;/h6-13H,4-5,14-16H2,1-3H3;1H
InChI key
JRNWTJUIMRLKBV-UHFFFAOYSA-N
Biochem/physiol Actions
Caroverine hydrochloride is a nonselective NMDA and AMPA glutamate receptor antagonist.
Caroverine hydrochloride is a nonselective NMDA and AMPA glutamate receptor antagonist. Also, Caroverine hydrochloride is a class B calcium-channel-blocker, antiglutamatergic agent, and acts as an antioxidant when administered to lab animals.
Features and Benefits
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Hans Nohl et al.
BioFactors (Oxford, England), 19(1-2), 79-85 (2004-02-06)
Here we show that lipid peroxidation of liposomal membranes was suppressed in the presence of Caroverine, a spasmolytic drug used in some countries. In order to understand the mechanism of this antioxidant action of Caroverine we studied the interaction of
B Schwab et al.
Laryngo- rhino- otologie, 83(3), 164-172 (2004-03-26)
The local therapy of inner ear diseases provides a means of directly applying pharmacological substances and delivering electrical stimulation to inner ear structures. Problems relating to dosage, systemic effects and the blood-cochlear barrier are thus avoided, which is not the
Christian Quint et al.
Acta oto-laryngologica, 122(8), 877-881 (2003-01-25)
The treatment of non-conductive olfactory disorders is to a large extent an unsolved problem. This proof-of-concept study focused on possible effects of the N-methyl-D-aspartate (NMDA) antagonist caroverine. Potential mechanisms for the hypothesized effect included reduced feedback inhibition in the olfactory
Caroverine in tinnitus treatment.
H Domeisen et al.
Acta oto-laryngologica, 118(4), 606-608 (1998-09-03)
Zhiqiang Chen et al.
Audiology & neuro-otology, 8(1), 49-56 (2003-02-05)
Caroverine, an N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist, has been shown to protect the inner ear from excitotoxicity and to be effective in the treatment of cochlear synaptic tinnitus. Local administration of caroverine on the round window membrane (RWM) could
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