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Merck
CN

C1119

Caroverine hydrochloride

≥98% (HPLC), solid

Synonym(s):

1-[2-(Diethylamino)ethyl]-3-[(4-methoxyphenyl)methyl]-2(1H)-quinoxalinone monohydrochloride

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About This Item

Empirical Formula (Hill Notation):
C22H28ClN3O2
CAS Number:
55750-05-5
Molecular Weight:
401.93
UNSPSC Code:
12352200
PubChem Substance ID:
329774856
MDL number:
MFCD01684929

Key Documents

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InChI

1S/C22H27N3O2.ClH/c1-4-24(5-2)14-15-25-21-9-7-6-8-19(21)23-20(22(25)26)16-17-10-12-18(27-3)13-11-17;/h6-13H,4-5,14-16H2,1-3H3;1H

SMILES string

Cl.CCN(CC)CCN1C(=O)C(Cc2ccc(OC)cc2)=Nc3ccccc13

InChI key

JRNWTJUIMRLKBV-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

solubility

DMSO: >10 mg/mL, H2O: insoluble

storage temp.

2-8°C

Biochem/physiol Actions

Caroverine hydrochloride is a nonselective NMDA and AMPA glutamate receptor antagonist.
Caroverine hydrochloride is a nonselective NMDA and AMPA glutamate receptor antagonist. Also, Caroverine hydrochloride is a class B calcium-channel-blocker, antiglutamatergic agent, and acts as an antioxidant when administered to lab animals.

Features and Benefits

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
058K4601

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Christian Quint et al.
Acta oto-laryngologica, 122(8), 877-881 (2003-01-25)
The treatment of non-conductive olfactory disorders is to a large extent an unsolved problem. This proof-of-concept study focused on possible effects of the N-methyl-D-aspartate (NMDA) antagonist caroverine. Potential mechanisms for the hypothesized effect included reduced feedback inhibition in the olfactory
Hans Nohl et al.
BioFactors (Oxford, England), 19(1-2), 79-85 (2004-02-06)
Here we show that lipid peroxidation of liposomal membranes was suppressed in the presence of Caroverine, a spasmolytic drug used in some countries. In order to understand the mechanism of this antioxidant action of Caroverine we studied the interaction of
B Schwab et al.
Laryngo- rhino- otologie, 83(3), 164-172 (2004-03-26)
The local therapy of inner ear diseases provides a means of directly applying pharmacological substances and delivering electrical stimulation to inner ear structures. Problems relating to dosage, systemic effects and the blood-cochlear barrier are thus avoided, which is not the
Elmar Oestreicher et al.
Advances in oto-rhino-laryngology, 59, 18-25 (2002-03-12)
Glutamate is the major transmitter candidate between inner hair cells and the afferent neurons of the mammalian cochlea. We investigated the action of memantine (1-amino-3,5-dimethyl-adamantane) and the quinoxaline derivative caroverine [1-diethylaminoethyl-3,8-(p-methoxybenzyl)-1,2-dihydro-quinoxaline-dione] on the glutamatergic transmission in the guinea pig cochlea
J Klement et al.
Diabetologia, 52(6), 1192-1196 (2009-04-04)
Glutamatergic pathways are assumed to play a critical role in the hormonal stress response to hypoglycaemia. In rats, glutamate signalling at the amino-3-hydroxy-5-methyl-4-isoxazol propionate (AMPA) receptor contributes to hormone release induced by behavioural stressors. We hypothesised that blocking the AMPA
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