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Merck
CN

C122

Codeine sulfate salt

Synonym(s):

3-Methylmorphine sulfate salt

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About This Item

Linear Formula:
C36H42N2O6 · H2SO4
CAS Number:
1420-53-7
Molecular Weight:
696.81
UNSPSC Code:
12352200
NACRES:
NA.77
EC Number:
215-818-5
MDL number:
MFCD02093595

Key Documents

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SMILES string

[S](=O)(=O)(O)O.N6([C@H]7[C@H]8[C@@]9([C@@H](Oc%10c9c(ccc%10OC)C7)[C@H](C=C8)O)CC6)C.N1([C@H]2[C@H]3[C@@]4([C@@H](Oc5c4c(ccc5OC)C2)[C@H](C=C3)O)CC1)C

InChI key

BCXHDORHMMZBBZ-DORFAMGDSA-N

InChI

1S/2C18H21NO3.H2O4S/c2*1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;1-5(2,3)4/h2*3-6,11-13,17,20H,7-9H2,1-2H3;(H2,1,2,3,4)/t2*11-,12+,13-,17-,18-;/m00./s1

form

solid

drug control

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada, kontrollierte Droge in Deutschland

Quality Level

100

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Biochem/physiol Actions

Narcotic analgesic and selective μ agonist whose activity is due to its conversion (demethylation) to morphine in vivo.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

新产品
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Certificates of Analysis (COA)

Lot/Batch Number
079H1482

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A Liguori et al.
The Journal of pharmacology and experimental therapeutics, 277(1), 462-472 (1996-04-01)
Respiratory and behavioral effects of the mu selective opioids levorphanol (0.01-3.0 mg/kg), methadone (0.03-5.6 mg/kg) and codeine (0.3-30.0 mg/kg) and the mixed-action opioids buprenorphine (0.003-10.0 mg/kg), butorphanol (0.003-0.3 mg/ kg) and nalbuphine (0.03-30.0 mg/kg) were studied in rhesus monkeys. In
I Tegeder et al.
Clinical pharmacokinetics, 37(1), 17-40 (1999-08-19)
The liver is the major site of biotransformation for most opioids. Thus, the disposition of these drugs may be affected in patients with liver insufficiency. The major metabolic pathway for most opioids is oxidation. The exceptions are morphine and buprenorphine
E A Pehek et al.
Pharmacology, biochemistry, and behavior, 36(2), 267-271 (1990-06-01)
The effects of the psychostimulant (+)cathine (norpseudoephedrine) were examined in a two-choice, food-motivated, drug-discrimination paradigm. Rats were able to discriminate cathine from vehicle and this effect was dose- and time-dependent. Prior administration of cathine resulted in a diminished response (tolerance)
M B Ahmed et al.
Journal of ethnopharmacology, 39(3), 213-216 (1993-08-01)
Catha edulis is a plant that grows in certain areas of East Africa and the Arab Peninsula. The stimulating properties of fresh material were described more than seven centuries ago and today the habit of inducing a state of euphoria

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