C1676
μ-Conotoxin GIIIB
~95% (HPLC)
Synonym(s):
Arg-Asp-Cys-Cys-Thr-Hyp-Hyp-Arg-Lys-Cys-Lys-Asp-Arg-Arg-Cys-Lys-Hyp-Met-Lys-Cys-Cys-Ala-NH2 [Disulfide bridges undefined], GTXII, Geographutoxin II
assay
~95% (HPLC)
composition
Peptide content, ~60%
storage temp.
−20°C
Biochem/physiol Actions
Vertebrate skeletal muscle Na+-channel blocker
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Kubo, S., et al.
Peptide Chem., 1989, 257-257 (1990)
S J Hong et al.
British journal of pharmacology, 97(3), 934-940 (1989-07-01)
1. Endplate potentials (e.p.ps) were investigated in the presence of geographutoxin II (GTXII) in the mouse phrenic nerve diaphragm preparation. This toxin preferentially blocks muscle Na+ channels which allows the study of e.p.ps in the absence of nicotinic receptor antagonists
L J Cruz et al.
The Journal of biological chemistry, 260(16), 9280-9288 (1985-08-05)
We describe the properties of a family of 22-amino acid peptides, the mu-conotoxins, which are useful probes for investigating voltage-dependent sodium channels of excitable tissues. The mu-conotoxins are present in the venom of the piscivorous marine snail, Conus geographus L.
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