C1688
Anti-C-Reactive Protein antibody, Mouse monoclonal
clone CRP-8, purified from hybridoma cell culture
Synonym(s):
Monoclonal Anti-C-Reactive Protein antibody produced in mouse, Anti-CRP
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About This Item
Conjugate:
unconjugated
Clone:
CRP-8, monoclonal
Application:
DB, ELISA (i), WB
Citations:
29
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
CRP-8, monoclonal
mol wt
antigen 24 kDa
contains
15 mM sodium azide
species reactivity
human
technique(s)
dot blot: suitable, indirect ELISA: 1:40,000-80,000, western blot: 1:200-400
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CRP(1401)
General description
C-reactive protein (CRP) is a member of the pentraxin family of proteins and synthesized by the liver. It is also known as PTX1. The CRP gene is mapped to human chromosome 1q23.2.
Immunogen
human C-reactive protein.
Application
- It has been used in immunoblotting assay, to identify monomeric CRP.
- In time-resolved fluorometric assay.
Monoclonal Anti-C-Reactive Protein antibody produced in mouse is suitable for the following:
- dot blot analysis
- indirect ELISA at a working dilution of 1:40,000
- western blotting at a working dilution of 1:200
Biochem/physiol Actions
C-reactive protein (CRP) shows essential scavenging and metabolic activity and is also associated with defence mechanism. It activates the complement pathway by binding to calcium-dependent exogenous and autologous molecules containing phosphocholine (PC). It may have pathogenic effects and is a practical prognostic marker in patients with hepatocellular carcinoma (HCC). The CRP diagnostic value is higher for acute pyelonephritis than lower urinary tract infection. Thus, it helps in differentiating between upper and lower urinary tract infection. It is considered best for predicting the risk of cardiovascular disease..
The antibody recognizes an epitope located on the 24 kDa subunit of denatured and reduced CRP. It does not cross-react with human serum amyloid P component (SAP), human haptoglobin, human α1-acid glycoprotein, human IgG, and CRP from Limulus.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
动植物来源生物产品
常规特殊物品
常规特殊物品
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C-reactive protein specifically enhances platelet-activating factor-induced inflammatory activity in vivo.
Sato A, et al.
European Journal of Pharmacology, 745, 46-51 (2014)
Birgit Fendl et al.
Scientific reports, 11(1), 6996-6996 (2021-03-28)
There is increasing evidence that C-reactive protein (CRP) can mediate inflammatory reactions following the transformation of functionally inert pentameric CRP (pCRP) into its structural isoform pCRP* and into monomeric CRP (mCRP). This conversion can occur on the membranes of apoptotic
The effect of C-reactive protein deposition on myocardium with ischaemia-reperfusion injury in rats.
Se Jin Oh et al.
Interactive cardiovascular and thoracic surgery, 25(2), 260-267 (2017-05-06)
We evaluated the effect of monomeric C-reactive protein (CRP) deposition on areas at risk (AAR) of myocardium with ischaemia-reperfusion injury. Myocardial ischaemia-reperfusion injury model was produced by ligation of the left anterior descending coronary artery for 45 min followed by 45 min
Aleksandra N Klisic et al.
Laboratory medicine, 45(1), 12-16 (2014-04-12)
Although C-reactive protein (CRP) is among the best cardiovascular disease risk predictors, data regarding the association of CRP and menopause are controversial. In this study, we measured CRP by a high-sensitivity method (hsCRP), cholesterol, lipoproteins, and triglycerides in normal and
Eun Na Kim et al.
Journal of chest surgery, 54(1), 9-16 (2021-03-27)
The deposition of monomeric C-reactive protein (mCRP) in the myocardium aggravates ischemia-reperfusion injury (IRI) and myocardial infarction. Ischemic preconditioning (IPC) is known to protect the myocardium against IRI. We evaluated the effects of IPC on myocardium upon which mCRP had
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