C188
6-Hydroxychlorzoxazone
solid
Synonym(s):
5-Chloro-6-hydroxy-2(3H)-benzoxazolone, 5-Chloro-6-hydroxybenzoxazone
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About This Item
Empirical Formula (Hill Notation):
C7H4ClNO3
CAS Number:
Molecular Weight:
185.56
UNSPSC Code:
12161501
PubChem Substance ID:
MDL number:
form
solid
solubility
H2O: insoluble, ethanol: moderately soluble
SMILES string
Oc1cc2OC(=O)Nc2cc1Cl
InChI
1S/C7H4ClNO3/c8-3-1-4-6(2-5(3)10)12-7(11)9-4/h1-2,10H,(H,9,11)
InChI key
AGLXDWOTVQZHIQ-UHFFFAOYSA-N
Application
CYP2E1 & 1A2 metabolite of chlorzoxazone.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Ko-Hsiu Lu et al.
Molecules (Basel, Switzerland), 26(1) (2020-12-31)
Osteosarcoma, the most prevalent malignant bone tumor in the pediatric age group, is responsible for the great majority of cancer-associated deaths owing to its highly metastatic potential. The anti-metastatic effects of the new curcumin analogue L48H37 in human osteosarcoma are
Won- Suk Chung et al.
Life sciences, 73(3), 253-263 (2003-05-22)
It has been reported from our laboratories that expression of CYP2E1 significantly increased and decreased in rats with acute renal failure induced by uranyl nitrate (U-ARF) treated with recombinant human growth hormone (rGH) for one day (U-ARF1) compared with those
P Piccoli et al.
Toxicology letters, 192(1), 29-33 (2009-11-11)
Assessing CYP2E1 phenotype in vivo may be important to predict individual susceptibility to those chemicals, including benzene, which are metabolically activated by this isoenzyme. Chlorzoxazone (CHZ), a specific CYP2E1 substrate, is readily hydroxylated to 6-OH-chlorzoxazone (6-OH-CHZ) by liver CYP2E1 and
M Reza Anari et al.
Analytical chemistry, 75(3), 469-478 (2003-02-15)
The application of liquid chromatography tandem mass spectrometry for simultaneous analysis of major human cytochrome P450 activities via a single atmospheric pressure ionization (API) LC/MS/MS method has been hampered by the preferred detection of 6-hydroxychlorzoxazone (HCZ), the metabolite of the
Reza Mehvar et al.
Journal of pharmaceutical sciences, 95(7), 1414-1424 (2006-05-26)
The steady-state disposition of chlorzoxazone (CZX) and its hydroxylated metabolite 6-hydroxychlorzoxazone (HCZX) was determined in a single-pass isolated perfused rat liver (IPRL) model using constant CZX concentrations of 10-200 microM. The concentrations of CZX, HCZX, and/or HCZX glucuronide in the
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 573128-10MG | 04055977190182 |
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