C1897
Catechol-O-methyl Transferase from porcine liver
lyophilized powder, ≥150 units/mg protein
Synonym(s):
COMT, Pyrocatechol-O-methyl Transferase, S-Adenosyl-L-methionine:catechol O-methyltransferase
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About This Item
CAS Number:
UNSPSC Code:
12352200
EC Number:
232-727-6
MDL number:
form
lyophilized powder
specific activity
≥150 units/mg protein
purified by
chromatography
composition
Protein, 30-60% biuret
storage temp.
−20°C
Biochem/physiol Actions
Major degradative enzyme for catecholamine neurotransmitters; methylates the o-hydroxyl group
Physical form
Lyophilized powder containing phosphate buffer and dithiothreitol
Other Notes
One unit will produce 1.0 nanomole of total O-methylated products from 3,4 dihydroxyacetophenone per hour at pH 7.6 at 37 °C.
Previous radioactive assay unit definition: One unit will catalyze the methylation of 1.0 nanomole of protocatechuic acid per hr at pH 7.9 at 37°C using S-adenosyl-L-[methyl-14C]methionine as the methyl donor. (~6 radioactive units equal one new unit).
Previous radioactive assay unit definition: One unit will catalyze the methylation of 1.0 nanomole of protocatechuic acid per hr at pH 7.9 at 37°C using S-adenosyl-L-[methyl-14C]methionine as the methyl donor. (~6 radioactive units equal one new unit).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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M C Wardle et al.
Genes, brain, and behavior, 12(1), 13-20 (2012-12-13)
In a widely cited study, Mattay et al. reported that amphetamine (0.25 mg/kg oral, or 17 mg for a 68 kg individual) impaired behavioral and brain indices of executive functioning, measured using the Wisconsin Card Sorting Task (WCST) and N-Back
Nidhi Jatana et al.
Journal of molecular graphics & modelling, 39, 145-164 (2013-01-03)
Catechol-O-methyltransferase (COMT) catalyzes the methylation of catecholamines, including neurotransmitters like dopamine, epinephrine and norepinephrine, leading to their degradation. COMT has been a subject of study for its implications in numerous neurological disorders like Parkinson's disease (PD), schizophrenia, and depression. The
Omer Ates et al.
Molecular and cellular biochemistry, 375(1-2), 179-183 (2012-12-15)
Uterine leiomyoma (ULM) is the most common gynecological benign tumor that is affecting around 20-50 % of women over the age of 30. Although its molecular pathogenesis is still unknown, ULM has a multifactorial etiology determined by both genetics and
Francesco Papaleo et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(49), 20160-20165 (2012-11-22)
Cognitive functioning differs between males and females, likely in part related to genetic dimorphisms. An example of a common genetic variation reported to have sexually dimorphic effects on cognition and temperament in humans is the Val/Met polymorphism in catechol-O-methyltransferase (COMT).
Ruth Landau et al.
Anesthesia and analgesia, 116(2), 386-391 (2013-01-11)
IV fentanyl is used as a labor analgesic; however, few studies have reported the effects of IV fentanyl for early labor analgesia. We evaluated the analgesic response to IV fentanyl according to the combined effect of the single-nucleotide polymorphisms rs1799971
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