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C199

CGS-15943

≥98% (HPLC), Adenosine receptor antagonist, solid

Synonym(s):

9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine

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About This Item

Empirical Formula (Hill Notation):
C13H8ClN5O
CAS Number:
104615-18-1
Molecular Weight:
285.69
UNSPSC Code:
12352202
PubChem Substance ID:
24277704
NACRES:
NA.77
MDL number:
MFCD01529897
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
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Product Name

CGS-15943, solid

assay

≥98% (HPLC)

Quality Level

100

form

solid

color

white

solubility

DMSO: >10 mg/mL, H2O: insoluble

storage temp.

room temp

SMILES string

Nc1nc2ccc(Cl)cc2c3nc(nn13)-c4ccco4

InChI

1S/C13H8ClN5O/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h1-6H,(H2,15,16)

InChI key

MSJODEOZODDVGW-UHFFFAOYSA-N

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora2b(29316)

Application

CGS-15943 has been used as a non-selective adenosine receptor antagonist to study its effects on the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and hepatocellular carcinoma (HCC). It has also been used as a non-selective adenosine receptor antagonist to investigate the mechanism underlying adenosine inhibition on cholangiocarcinoma (CCA) cells.

Biochem/physiol Actions

CGS-15943 is a potent and non-selective adenosine receptor antagonist. It exhibits anti-carcinogenic and anti-apoptotic activity.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000364481
0000364481
0000216290
0000216290
0000209086

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A C Ngai et al.
American journal of physiology. Heart and circulatory physiology, 280(5), H2329-H2335 (2001-04-12)
The purpose of this study was to investigate the receptor subtypes that mediate the dilation of rat intracerebral arterioles elicited by adenosine. Penetrating arterioles were isolated from the rat brain, cannulated with the use of a micropipette system, and luminally
M Williams et al.
The Journal of pharmacology and experimental therapeutics, 241(2), 415-420 (1987-05-01)
CGS 15943A, a triazoloquinazoline, is a potent and selective adenosine receptor antagonist as assessed by its effects on radioligand binding and adenosine-stimulated adenylate cyclase activity in guinea pig synaptoneurosomes. At the adenosine A-1 receptor labeled with [3H]cyclohexyladenosine, CGS 15943A had
Soo-Kyung Kim et al.
Journal of medicinal chemistry, 46(23), 4847-4859 (2003-10-31)
A three-dimensional model of the human A(2A) adenosine receptor (AR) and its docked ligands was built by homology to rhodopsin and validated with site-directed mutagenesis and the synthesis of chemically complementary agonists. Different binding modes of A(2A)AR antagonists and agonists
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Global Trade Item Number

SKUGTIN
C199-25MG04061833474914