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Merck
CN

C199

CGS-15943

≥98% (HPLC), Adenosine receptor antagonist, solid

Synonym(s):

9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine

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About This Item

Empirical Formula (Hill Notation):
C13H8ClN5O
CAS Number:
104615-18-1
Molecular Weight:
285.69
MDL number:
MFCD01529897
UNSPSC Code:
12352202
PubChem Substance ID:
24277704
NACRES:
NA.77

Key Documents

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Product Name

CGS-15943, solid

Assay

≥98% (HPLC)

Quality Level

100

form

solid

color

white

solubility

DMSO: >10 mg/mL
H2O: insoluble

storage temp.

room temp

SMILES string

Nc1nc2ccc(Cl)cc2c3nc(nn13)-c4ccco4

InChI

1S/C13H8ClN5O/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h1-6H,(H2,15,16)

InChI key

MSJODEOZODDVGW-UHFFFAOYSA-N

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora2b(29316)

Related Categories

Application

CGS-15943 has been used as a non-selective adenosine receptor antagonist to study its effects on the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and hepatocellular carcinoma (HCC). It has also been used as a non-selective adenosine receptor antagonist to investigate the mechanism underlying adenosine inhibition on cholangiocarcinoma (CCA) cells.

Biochem/physiol Actions

CGS-15943 is a potent and non-selective adenosine receptor antagonist. It exhibits anti-carcinogenic and anti-apoptotic activity.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000364481
0000364481
0000216290
0000216290
0000209086

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M Williams et al.
The Journal of pharmacology and experimental therapeutics, 241(2), 415-420 (1987-05-01)
CGS 15943A, a triazoloquinazoline, is a potent and selective adenosine receptor antagonist as assessed by its effects on radioligand binding and adenosine-stimulated adenylate cyclase activity in guinea pig synaptoneurosomes. At the adenosine A-1 receptor labeled with [3H]cyclohexyladenosine, CGS 15943A had
A C Ngai et al.
American journal of physiology. Heart and circulatory physiology, 280(5), H2329-H2335 (2001-04-12)
The purpose of this study was to investigate the receptor subtypes that mediate the dilation of rat intracerebral arterioles elicited by adenosine. Penetrating arterioles were isolated from the rat brain, cannulated with the use of a micropipette system, and luminally
J m Li et al.
The Journal of surgical research, 80(2), 357-364 (1999-01-08)
Adenosine is a potent vasodilator of vascular smooth muscle. Endothelium-derived nitric oxide (NO) elicits vasodilation. We have previously reported that adenosine stimulates the production of NO from porcine carotid arterial endothelial cells (PCAEC) via a receptor-mediated mechanism. This study was
Zhan-Guo Gao et al.
Cells, 9(5) (2020-05-16)
Allosteric antagonism by bitopic ligands, as reported for many receptors, is a distinct modulatory mechanism. Although several bitopic A2A adenosine receptor (A2AAR) ligand classes were reported as pharmacological tools, their receptor binding and functional antagonism patterns, i.e., allosteric or competitive
E Ongini et al.
Naunyn-Schmiedeberg's archives of pharmacology, 359(1), 7-10 (1999-02-05)
Three structurally related non-xanthine compounds, CGS 15943, ZM 241385 and SCH 58261, are potent A2A adenosine receptor antagonists and have been used as tools in many pharmacological studies. We have now characterized their affinity and selectivity profile on human adenosine
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