C209
Clobenpropit dihydrobromide
solid
Synonym(s):
VUF 9153, [(4-Chlorophenyl)methyl]-3-(1H-imidazol-4-yl)propyl ester carbamimidothioic acid dihydrobromide
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About This Item
Empirical Formula (Hill Notation):
C14H17ClN4S · 2HBr
CAS Number:
Molecular Weight:
470.65
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
form
solid
color
white
solubility
H2O: >20 mg/mL
ethanol: 3.30 mg/mL
DMSO: >30 mg/mL
storage temp.
2-8°C
SMILES string
Br[H].Br[H].Clc1ccc(CNC(=N)SCCCc2c[nH]cn2)cc1
InChI
1S/C14H17ClN4S.2BrH/c15-12-5-3-11(4-6-12)8-18-14(16)20-7-1-2-13-9-17-10-19-13;;/h3-6,9-10H,1-2,7-8H2,(H2,16,18)(H,17,19);2*1H
InChI key
JIJQPEZAVLJZBO-UHFFFAOYSA-N
Biochem/physiol Actions
Selective H3 histamine receptor antagonist that crosses the blood-brain barrier.
Features and Benefits
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Disclaimer
Hygroscopic
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Danish Mahmood et al.
Pharmacological reports : PR, 64(1), 191-204 (2012-05-15)
Schizophrenia (SCZ) afflicts around 1% of the world's population with characteristic symptoms such as hallucinations, delusions, and cognitive disorders. Several experimental studies in the past have indicted brain histaminergic neuronal system involvement in the pathogenesis of psychotic disorders including SCZ.
Brajesh K Rai et al.
Proteins, 78(2), 457-473 (2009-09-30)
G Protein-Coupled Receptors (GPCRs) are integral membrane proteins that play important role in regulating key physiological functions, and are targets of about 50% of all recently launched drugs. High-resolution experimental structures are available only for very few GPCRs. As a
Kasper B Hansen et al.
The Journal of pharmacology and experimental therapeutics, 333(3), 650-662 (2010-03-04)
N-Methyl-D-aspartate (NMDA) receptors are ligand-gated ion channels that mediate a slow, Ca(2+)-permeable component of excitatory synaptic transmission in the central nervous system and play a pivotal role in synaptic plasticity, neuronal development, and several neurological diseases. We describe a fluorescence-based
W Bäumer et al.
Allergy, 63(10), 1387-1394 (2008-09-11)
Dendritic cells (DC) are the major antigen-presenting cells and play a key role in adaptive immunity as they are able to activate naive T cells. It was recently described, that the histamine H(4) receptor (H4R) is present on human monocyte-derived
Fanyin Meng et al.
Hepatology (Baltimore, Md.), 54(5), 1718-1728 (2011-07-28)
Cholangiocarcinoma (CCA) is a biliary cancer arising from damaged bile ducts. Epithelial-mesenchymal transition (EMT) occurs as epithelial cells begin to resemble mesenchymal cells leading to increased invasion potential as the extracellular matrix (ECM) degrades. Histamine exerts its effects by way
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