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Merck
CN

C209

Clobenpropit dihydrobromide

solid

Synonym(s):

VUF 9153, [(4-Chlorophenyl)methyl]-3-(1H-imidazol-4-yl)propyl ester carbamimidothioic acid dihydrobromide

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About This Item

Empirical Formula (Hill Notation):
C14H17ClN4S · 2HBr
CAS Number:
145231-45-4
Molecular Weight:
470.65
NACRES:
NA.77
PubChem Substance ID:
24892464
UNSPSC Code:
12352200
MDL number:
MFCD00467655

Key Documents

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Product Name

Clobenpropit dihydrobromide, solid

InChI

1S/C14H17ClN4S.2BrH/c15-12-5-3-11(4-6-12)8-18-14(16)20-7-1-2-13-9-17-10-19-13;;/h3-6,9-10H,1-2,7-8H2,(H2,16,18)(H,17,19);2*1H

SMILES string

Br[H].Br[H].Clc1ccc(CNC(=N)SCCCc2c[nH]cn2)cc1

InChI key

JIJQPEZAVLJZBO-UHFFFAOYSA-N

form

solid

color

white

solubility

H2O: >20 mg/mL
ethanol: 3.30 mg/mL
DMSO: >30 mg/mL

storage temp.

2-8°C

Biochem/physiol Actions

Selective H3 histamine receptor antagonist that crosses the blood-brain barrier.

Disclaimer

Hygroscopic

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBZ7471
SLBS3256V
SLBS3253V
SLBH7940V
SLBH1668V

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Fanyin Meng et al.
Hepatology (Baltimore, Md.), 54(5), 1718-1728 (2011-07-28)
Cholangiocarcinoma (CCA) is a biliary cancer arising from damaged bile ducts. Epithelial-mesenchymal transition (EMT) occurs as epithelial cells begin to resemble mesenchymal cells leading to increased invasion potential as the extracellular matrix (ECM) degrades. Histamine exerts its effects by way
Brajesh K Rai et al.
Proteins, 78(2), 457-473 (2009-09-30)
G Protein-Coupled Receptors (GPCRs) are integral membrane proteins that play important role in regulating key physiological functions, and are targets of about 50% of all recently launched drugs. High-resolution experimental structures are available only for very few GPCRs. As a
Kasper B Hansen et al.
The Journal of pharmacology and experimental therapeutics, 333(3), 650-662 (2010-03-04)
N-Methyl-D-aspartate (NMDA) receptors are ligand-gated ion channels that mediate a slow, Ca(2+)-permeable component of excitatory synaptic transmission in the central nervous system and play a pivotal role in synaptic plasticity, neuronal development, and several neurological diseases. We describe a fluorescence-based
W Bäumer et al.
Allergy, 63(10), 1387-1394 (2008-09-11)
Dendritic cells (DC) are the major antigen-presenting cells and play a key role in adaptive immunity as they are able to activate naive T cells. It was recently described, that the histamine H(4) receptor (H4R) is present on human monocyte-derived
M Kathmann et al.
Naunyn-Schmiedeberg's archives of pharmacology, 348(5), 498-503 (1993-11-01)
We determined the affinities of nordimaprit, homodimaprit, clobenpropit and imetit for H3 binding sites (labelled by 3H-N alpha-methylhistamine) in rat brain cortex homogenates and their potencies at presynaptic H3A receptors on noradrenergic nerve endings in mouse brain cortex slices. 3H-N
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