C216
Calciseptine from Dendroaspis polylepis polylepis (black mamba)
>98%, amorphous powder
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About This Item
Empirical Formula (Hill Notation):
C299H468N90O87S10
CAS Number:
Molecular Weight:
7036.12
UNSPSC Code:
12352200
MDL number:
assay
>98%
form
amorphous powder
storage temp.
−20°C
Biochem/physiol Actions
Selective L-type Ca2+ channel blocker; from the venom of the black mamba Dendroaspis polylepis polylepis.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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O Yasuda et al.
Biochemical and biophysical research communications, 194(2), 587-594 (1993-07-30)
Calciseptine (CaS) is a natural peptidic L-type Ca2+ channel blocker consisting of 60 amino acids with four disulfide bonds. The effects of synthetic CaS on the binding of various ligands to Ca2+ channels of rat brain synaptosomal membranes were studied.
J R de Weille et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(6), 2437-2440 (1991-03-15)
The venom of the black mamba contains a 60-amino acid peptide called calciseptine. The peptide has been fully sequenced. It is a smooth muscle relaxant and an inhibitor of cardiac contractions. Its physiological action resembles that of drugs, such as
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