C261
Cytokine Responsive Gene-2 from mouse
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym(s):
CRG-2/1P-10
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About This Item
UNSPSC Code:
51111800
MDL number:
biological source
mouse
recombinant
expressed in E. coli
assay
≥97% (SDS-PAGE)
form
lyophilized powder
potency
0.8- 2.5 mg per mL ED50
mol wt
~8.8 kDa
storage condition
avoid repeated freeze/thaw cycles (Storage in "frost-free" freezers is not recommended)
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Cxcl10(15945)
Biochem/physiol Actions
The gene for CRG-2 (mouse homologue of human IP-10), identified as an immediate early gene induced in response to macrophage activation, is reported to be an inhibitor of angiogenesis and displays thymus-dependent anti-tumor effects. CRG-2 mRNA is induced by α/β/γ-interferons and by lipopolysaccharide in macrophages, astrocytes and microglia. CRG-2 shares approximately 67% sequence identity with human IP-10.
Physical form
Lyophilized from 30% acetonitrile and 0.1% trifluoroacetic acid containing 0.5 mg bovine serum albumin.
Analysis Note
The biological activity is measured by its ability to chemoattract human lymphocytes cultured in the presence of IL-2 for 8-10 days.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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P Vanguri
Journal of neuroimmunology, 56(1), 35-43 (1995-01-01)
We compared the expression of various interferon-gamma (IFN-gamma)-inducible mRNAs in primary rat astrocytes and microglia. Of 11 different mRNAs inducible by IFN-gamma in a macrophage cell line, RAW 264.7, only eight were induced in both types of glia, which included
M Loetscher et al.
The Journal of experimental medicine, 184(3), 963-969 (1996-09-01)
A human receptor that is selective for the CXC chemokines IP10 and Mig was cloned and characterized. The receptor cDNA has an open reading frame of 1104-bp encoding a protein of 368 amino acids with a molecular mass of 40,659
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