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Merck
CN

C2979

Caspase 7 human

≥95% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous solution, ≥1,500 units/mg protein

Synonym(s):

CMH-1, ICE-LAP3, Mch-3

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
MFCD01865995

Key Documents

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Product Name

Caspase 7 human, ≥95% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous solution, ≥1,500 units/mg protein

recombinant

expressed in E. coli

assay

≥95% (SDS-PAGE)

form

buffered aqueous solution

specific activity

≥1,500 units/mg protein

mol wt

56 kDa by immunoblotting

UniProt accession no.

P55210

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... CASP7(840)

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Analysis Note

Migrates as two major polypeptides (20 kDa and 10 kDa) in immunoblotting. Two minor polypeptides derived from the large subunit are also present.

Biochem/physiol Actions

Cleaves the substrates consisting of consensus sequence DEVD.
Useful in screening caspase inhibitors, studying enzyme regulation, determining specificities of caspase substrates, as well as using as a positive control in caspase activity assays and Western blot analyses.
Member of the CED-3 subfamily, the effector caspases, with an essential role in the apoptotic process. Upon activation, the zymogen is translocated to the mitochondrial and microsomal fractions. It is responsible for the cleavage of cellular substrates that precipitate the morphological changes of apoptosis.
Member of the CED-3 subfamily, the effector caspases; upon activation, the zymogen is translocated to the mitochondrial and microsomal fractions.

Other Notes

One unit will hydrolyze 1.0 nmol of Ac-Asp-Glu-Val-Asp-AFC per minute at pH 7.5 at 25 °C.

Physical form

Solution in HEPES, NaCl, DTT and sucrose, without carrier protein

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBN7324V
109K1635
039K1073
126K1279
090K1086

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J M Chandler et al.
The Journal of biological chemistry, 273(18), 10815-10818 (1998-06-06)
Caspases plays a key role in the execution phase of apoptosis. "Initiator" caspases, such as caspase-8, activate "effector" caspases, such as caspase-3 and -7, which subsequently cleave cellular substrates thereby precipitating the dramatic morphological changes of apoptosis. Following treatment of

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