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Merck
CN

C3241

Anti-CCR-7 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-C-C Chemokine Receptor 7

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About This Item

UNSPSC Code:
51111800
NACRES:
NA.41
MDL number:
MFCD03455130
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (p)
Citations:
3

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

availability

not available in Japan

concentration

~1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable

UniProt accession no.

P32248

shipped in

dry ice

storage temp.

−20°C

Quality Level

200

Gene Information

human ... CCR7(1236)
mouse ... Ccr7(12775)
rat ... Ccr7(287673)

Immunogen

synthetic peptide corresponding to the C-terminal domain of human C-C chemokine receptor 7 (CCR7), conjugated to KLH.

Biochem/physiol Actions

CCR-7 is a G protein-coupled receptor that activates B and T lymphocytes. It mediates the effects of Epstein-Barr virus on B lymphocytes, regulates the migration of memory T cells to sites of inflammation and stimulates dendritic cell maturation.

Physical form

Solution in phosphate buffered saline, pH 7.7, containing 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBX0648
051M1344
SLBD3332
038K1596
037K1518

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Marc-André Allaire et al.
Immunology letters, 146(1-2), 70-73 (2012-06-05)
Prostaglandin E(2) (PGE(2)) induces the expression of C-C chemokine receptor type 7 (CCR7) on human monocytes, thereby enabling their subsequent migration in response to CCL19 and CCL21, the natural ligands for CCR7. To date, important mediators of PGE(2)-mediated monocyte migration
Karin Schaeuble et al.
Journal of cell science, 125(Pt 19), 4463-4474 (2012-07-17)
The chemokine receptor CCR7 is essential for lymphocyte and dendritic cell homing to secondary lymphoid organs. Owing to the ability to induce directional migration, CCR7 and its ligands CCL19 and CCL21 are pivotal for the regulation of the immune system.
Praveen Akuthota et al.
American journal of respiratory cell and molecular biology, 48(6), 758-764 (2013-03-02)
Human eosinophils display directed chemotactic activity toward an array of soluble chemokines. Eosinophils have been observed to migrate to draining lymph nodes in experimental models of allergic inflammation, yet it is unknown whether eosinophils express CCR7, a key chemokine receptor

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