C4499
Cytochrome P450 Microsome Preparation human
Neagtive Control without NADPH reductase, Produced in Saccharomyces cerevisiae
Synonym(s):
Cerosomes
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biological source
human
form
solution
UniProt accession no.
application(s)
cell analysis
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... CYP2C9(1559)
Application
Cytochrome P450 Microsome Preparation Human, product C4499, is a negative control without NADPH reductase and is produced in Saccharomyces cervisiae. Cytochrome P450 is used to catalyze the oxidative metabolism of xenobiotics and to study the biotransformation and elimination of drugs and pollutants from the body. Cytochrome P450 is used to study hormone synthesis and breakdown, cholesterol synthesis, drug metabolism and bioactivation and vitamin D metabolism. Cytochrome P450 has been used as a negative control during the examination of CYP2S1 catalytic activity .
Biochem/physiol Actions
Microsomal cytochrome P450 enzymes are found primarily in the endoplasmic reticulum of liver tissue. They catalyze the oxidative metabolism of xenobiotics and are the major enzymes involved in drug metabolism and bioactivation. The reactions are achieved through a mixed monooxygenase system. The cytochrome P450 enzymes range in molecular mass between 45-60 kDa.
Physical form
Supplied as a solution containing 50 mM potassium phosphate, pH 7.4, 5% glycerol, 1 mM EDTA, 1 mM PMSF, and 2 mM DTT
Other Notes
For more more information visit our drug metabolism resources for Cytochrome P450 microsome preparations.
Regulatory Information
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F Peter Guengerich
Chemical research in toxicology, 21(1), 70-83 (2007-12-07)
The field of cytochrome P450 (P450) research has developed considerably over the past 20 years, and many important papers on the roles of P450s in chemical toxicology have appeared in Chemical Research in Toxicology. Today, our basic understanding of many
Peter H Bui et al.
Molecular pharmacology, 76(5), 1031-1043 (2009-08-29)
Human cytochrome P450 2S1 was recently identified and shown to be inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin and hypoxia. It is highly expressed in epithelial cells of tissues that are exposed to the environment and in many tumors of epithelial origin. The biological