C5021
Acetylcholinesterase from bovine erythrocytes
Type XII-S, lyophilized powder, 0.25-1.0 unit/mg solid
Synonym(s):
AChE, Acetylcholine Esterase, membrane-bound, from bovine erythrocytes, Acetylcholine acetylhydrolase
type
Type XII-S
form
lyophilized powder
specific activity
0.25-1.0 unit/mg solid
UniProt accession no.
storage temp.
−20°C
Gene Information
cow ... ACHE(540446)
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Biochem/physiol Actions
Major degradative enzyme for acetylcholine in vivo. Converts acetylcholine + H2O to choline + acetic acid.
Physical form
Lyophilized powder containing phosphate buffer salts
Analysis Note
The activity obtained using acetylcholine as substrate is 30-100 times that obtained with butyrylcholine, using acetylcholinesterase from electric eel.
Other Notes
Activity believed to be membrane (stroma) bound.
One unit will hydrolyze 1.0 μmole of acetylcholine to choline and acetate per min at pH 8.0 at 37 °C.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Mariah L Scott et al.
Journal of the American Mosquito Control Association, 28(4), 323-326 (2013-02-12)
Insecticide resistance to organophosphates and carbamates can be the result of changes in acetylcholinesterase activity conferred by the ACE-1 mutation. Detection of this altered target site mutation is important in guiding informed decisions for resistance management. In this study we
Colonic perforation in a case of adult Hirschsprung's disease with acetylcholinesterase-negative neuronal fibers.
Naruhiko Ikoma et al.
The American surgeon, 79(3), E130-E132 (2013-03-07)
Heng Luo et al.
Journal of microbiology and biotechnology, 23(2), 161-166 (2013-02-16)
At present, acetylcholinesterase (AChE) inhibitors are the first group of drugs to treat mild to moderate Alzheimer's disease (AD). Although beneficial in improving cognitive and behavioral symptoms, the effectiveness of AChE inhibitors has been questioned since they do not delay
Marc W van der Kamp et al.
Biochemistry, 52(16), 2708-2728 (2013-04-06)
Computational enzymology is a rapidly maturing field that is increasingly integral to understanding mechanisms of enzyme-catalyzed reactions and their practical applications. Combined quantum mechanics/molecular mechanics (QM/MM) methods are important in this field. By treating the reacting species with a quantum
Michael R Reddy et al.
The American journal of tropical medicine and hygiene, 88(5), 897-907 (2013-02-27)
Anti-malaria interventions that rely on insecticides can be compromised by insecticide-resistance alleles among malaria vectors. We examined frequency changes of resistance alleles at two loci, knockdown resistance (kdr) and acetylcholinesterase-1 (ace-1), which confer resistance to pyrethroids and DDT, and carbamates
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