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C5108

Cathepsin G from human sputum

Name: Cathepsin G from human sputum
Brand: SIGMA

≥0.2 units/mg protein, salt-free, lyophilized powder

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About This Item

CAS Number:

107200-92-0

UNSPSC Code:

12352200

NACRES:

NA.32

EC Number:

3.4.21.20 (BRENDA, IUBMB)

MDL number:

MFCD00130750

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Properties

biological source

human sputum

form

salt-free, lyophilized powder

specific activity

≥0.2 units/mg protein

UniProt accession no.

P08311

shipped in

wet ice

storage temp.

2-8°C

Gene Information

human ... CTSG(1511)

Description

Biochem/physiol Actions

Cathepsin G has pro-apoptotic activity and can activate caspases in vitro.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Cathepsin G inhibitor prevents ultraviolet B-induced photoaging in hairless mice via inhibition of fibronectin fragmentation.

E D Son et al.

Dermatology (Basel, Switzerland), 224(4), 352-360 (2012-07-05)

Cathepsin G, a serine protease that is activated by ultraviolet (UV) radiation, increases matrix metalloproteinase-1 (MMP-1) expression in fibroblasts through fibronectin (Fn) fragmentation and promotes the conversion of proMMP-1 to active MMP-1. This study investigated whether [2-[3-[[(1-benzoyl-4-piperidinyl)methylamino]carbonyl]-2-naphthalenyl]-1-(1-naphthalenyl)-2-oxoethyl]-phosphonic acid (KPA), a

Simukunin from the salivary glands of the black fly Simulium vittatum inhibits enzymes that regulate clotting and inflammatory responses.

Hitoshi Tsujimoto et al.

PloS one, 7(2), e29964-e29964 (2012-03-03)

Black flies (Diptera: Simuliidae) feed on blood, and are important vectors of Onchocerca volvulus, the etiolytic agent of River Blindness. Blood feeding depends on pharmacological properties of saliva, including anticoagulation, but the molecules responsible for this activity have not been

5-Hydroxy-7-methoxyflavone inhibits N-formyl-L-methionyl-L-leucyl-L-phenylalanine-induced superoxide anion production by specific modulate membrane localization of Tec with a PI3K independent mechanism in human neutrophils.

Hsiang-Ruei Liao et al.

Biochemical pharmacology, 84(2), 182-191 (2012-04-10)

Respiratory burst mediates crucial bactericidal mechanism in neutrophils. However, undesirable respiratory burst leads to pathological inflammation and tissue damage. This study investigates the effect and the underlying mechanism of 5-hydroxy-7-methoxyflavone (MCL-1), a lignan extracted from the leaves of Muntingia calabura

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