C5492
CIL-102
≥95% (HPLC), solid
Synonym(s):
1-[4-(Furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone
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About This Item
Empirical Formula (Hill Notation):
C19H14N2O2
CAS Number:
Molecular Weight:
302.33
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
VJDPGTFIMDGXDQ-UHFFFAOYSA-N
SMILES string
CC(=O)c1ccc(Nc2c3ccccc3nc4occc24)cc1
InChI
1S/C19H14N2O2/c1-12(22)13-6-8-14(9-7-13)20-18-15-4-2-3-5-17(15)21-19-16(18)10-11-23-19/h2-11H,1H3,(H,20,21)
assay
≥95% (HPLC)
form
solid
solubility
DMSO: 12 mg/mL
shipped in
wet ice
storage temp.
−20°C
Biochem/physiol Actions
CIL-102 is a tubulin polymerization inhibitor: apoptosis inducer.
Legal Information
US Patent No. 6,750,223. Sold for non-human research purposes under a non-exclusive license agreement with Kaohsiung Medical University.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Wen-Shih Huang et al.
PloS one, 12(1), e0168989-e0168989 (2017-01-10)
CIL-102 (1-[4-(furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone) is a well-known, major active agent of the alkaloid derivative of Camptotheca acuminata with valuable biological properties, including anti-tumorigenic activity. In this study, we investigated the molecular mechanisms by which CIL-102 mediated the induction of cell death, and
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