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C5492

CIL-102

Name: CIL-102
Brand: SIGMA

≥95% (HPLC), solid

Synonym(s):

1-[4-(Furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₁₄N₂O₂

CAS Number:

479077-76-4

Molecular Weight:

302.33

NACRES:

NA.77

PubChem Substance ID:

24724444

UNSPSC Code:

12352200

MDL number:

MFCD08277043

Assay:

≥95% (HPLC)

Form:

solid

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assay

≥95% (HPLC)

form

solid

solubility

DMSO: 12 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

CC(=O)c1ccc(Nc2c3ccccc3nc4occc24)cc1

InChI

1S/C19H14N2O2/c1-12(22)13-6-8-14(9-7-13)20-18-15-4-2-3-5-17(15)21-19-16(18)10-11-23-19/h2-11H,1H3,(H,20,21)

InChI key

VJDPGTFIMDGXDQ-UHFFFAOYSA-N

Biochem/physiol Actions

CIL-102 is a tubulin polymerization inhibitor: apoptosis inducer.

Legal Information

US Patent No. 6,750,223. Sold for non-human research purposes under a non-exclusive license agreement with Kaohsiung Medical University.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

016K4703

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CIL-102-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells via Upregulation of p21 and GADD45.

Wen-Shih Huang et al.

PloS one, 12(1), e0168989-e0168989 (2017-01-10)

CIL-102 (1-[4-(furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone) is a well-known, major active agent of the alkaloid derivative of Camptotheca acuminata with valuable biological properties, including anti-tumorigenic activity. In this study, we investigated the molecular mechanisms by which CIL-102 mediated the induction of cell death, and

Global Trade Item Number

SKU	GTIN
C5492-10MG	04061833502228

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