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Merck
CN

C5492

Sigma-Aldrich

CIL-102

≥95% (HPLC), solid

Synonym(s):

1-[4-(Furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone

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About This Item

Empirical Formula (Hill Notation):
C19H14N2O2
CAS Number:
Molecular Weight:
302.33
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Assay

≥95% (HPLC)

form

solid

solubility

DMSO: 12 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

CC(=O)c1ccc(Nc2c3ccccc3nc4occc24)cc1

InChI

1S/C19H14N2O2/c1-12(22)13-6-8-14(9-7-13)20-18-15-4-2-3-5-17(15)21-19-16(18)10-11-23-19/h2-11H,1H3,(H,20,21)

InChI key

VJDPGTFIMDGXDQ-UHFFFAOYSA-N

Biochem/physiol Actions

CIL-102 is a tubulin polymerization inhibitor: apoptosis inducer.

Legal Information

US Patent No. 6,750,223. Sold for non-human research purposes under a non-exclusive license agreement with Kaohsiung Medical University.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Wen-Shih Huang et al.
PloS one, 12(1), e0168989-e0168989 (2017-01-10)
CIL-102 (1-[4-(furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone) is a well-known, major active agent of the alkaloid derivative of Camptotheca acuminata with valuable biological properties, including anti-tumorigenic activity. In this study, we investigated the molecular mechanisms by which CIL-102 mediated the induction of cell death, and

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