C5732
CA-074
synthetic (organic), ≥98% (HPLC), cathepsin B inhibitor, powder
Synonym(s):
(L-3-trans-(Propylcarbamyl)oxirane-2-carbonyl)-
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About This Item
Empirical Formula (Hill Notation):
C18H29N3O6
CAS Number:
Molecular Weight:
383.44
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Product Name
CA-074, ≥98% (HPLC)
biological source
synthetic (organic)
Quality Segment
assay
≥98% (HPLC)
form
powder
solubility
methanol: 1 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
CCCNC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H]([C@H](C)CC)C(=O)N2CCC[C@H]2C(O)=O
InChI
1S/C18H29N3O6/c1-4-8-19-15(22)13-14(27-13)16(23)20-12(10(3)5-2)17(24)21-9-6-7-11(21)18(25)26/h10-14H,4-9H2,1-3H3,(H,19,22)(H,20,23)(H,25,26)/t10?,11-,12-,13-,14-/m0/s1
InChI key
ZEZGJKSEBRELAS-NSIINPIOSA-N
Application
CA-074 has been used as a cathepsin B inhibitor:
- to study its effect on pseudotyped viruses bearing S proteins harboring R642M and N714K using HeLa cells
- to determine the role of autophagy in glucose deprivation (GD)-induced damage
- to study its effects on neuronal function upon exposure to His-cathepsin B (CATB)
Biochem/physiol Actions
CA-074 is a potent and a selective inhibitor of cathepsin B. It is useful to study the biological function of cathepsin B in vivo. Studies show that CA-074 can also inhibit cathepsin L under reducing conditions.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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