C5848
Monoclonal Anti-CCR-2 antibody produced in mouse
clone 48607.121, purified immunoglobulin, lyophilized powder
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About This Item
UNSPSC Code:
51111800
MDL number:
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
48607.121, monoclonal
form
lyophilized powder
species reactivity
human
technique(s)
flow cytometry: suitable
isotype
IgG2b
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... CCR2(729230)
mouse ... Ccr2(12772)
General description
C-C chemokine receptor type 2 (CCR-2) is a protein that belongs to chemokine cytokine family and is expressed mainly on monocytes. It has a crucial role in activation and migration of leukocytes. It also facilitates in the pathogenesis of vasculitis in Kawasaki disease (KD) . Monoclonal Anti-CCR-2 antibody can be used in flow cytometry for the Identification of human CCR-2. Mouse anti-CCR-2 antibody reacts specifically with CCR-2 transfected cells but not with the parent cell line. No cross reactivity has been observed with CCR-5 transfected cells.
Immunogen
human CCR-2 transfected NSO mouse myeloma cells.
Application
Monoclonal Anti-CCR-2 antibody can be used as a positive control in immunohistochemical staining.
Biochem/physiol Actions
The antibody reacts with CCR-2 transfectant cells and not the parent cell line. It shows no cross-reactivity with CCR-5 transfectant cells.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
Preparation Note
Purified using protein G.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Hernan G Martinez et al.
BMC immunology, 13, 56-56 (2012-10-19)
Chemokines and their receptors play a role in the innate immune response as well as in the disruption of the balance between pro-inflammatory Th17 cells and regulatory T cells (Treg), underlying the pathogenesis of coronary vasculitis in Kawasaki disease (KD).
A M Aragay et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(6), 2985-2990 (1998-04-18)
Monocyte chemoattractant protein 1 (MCP-1) is a member of the chemokine cytokine family, whose physiological function is mediated by binding to the CCR2 and CCR4 receptors, which are members of the G protein-coupled receptor family. MCP-1 plays a critical role
S Kobayashi et al.
Rheumatology (Oxford, England), 47(9), 1317-1322 (2008-07-12)
Environmental factors are involved in RA pathogenesis and epidemiological studies have suggested that smoking is an environmental risk factor for RA. The 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is one of the major toxic components in cigarettes. To clarify the biological effects of smoking
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