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Merck
CN

C5849

CHAPS

≥98%

Synonym(s):

3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate

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About This Item

Empirical Formula (Hill Notation):
C32H58N2O7S
CAS Number:
75621-03-3
Molecular Weight:
614.88
UNSPSC Code:
12161700
MDL number:
MFCD00012116

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InChI key

UMCMPZBLKLEWAF-RFCNGIAKSA-N

InChI

1S/C32H58N2O7S/c1-21(8-11-29(38)33-14-6-15-34(4,5)16-7-17-42(39,40)41)24-9-10-25-30-26(20-28(37)32(24,25)3)31(2)13-12-23(35)18-22(31)19-27(30)36/h21-28,30,35-37H,6-20H2,1-5H3,(H-,33,38,39,40,41)/t21-,22?,23-,24-,25+,26+,27-,28+,30+,31+,32-/m1/s1

SMILES string

C[C@H](CCC(=O)NCCC[N+](C)(C)CCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)CC4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C

assay

≥98%

mol wt

micellar avg mol wt 6150

aggregation number

10

CMC

6 mM (20-25°C)

transition temp

cloud point >100 °C

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Application

CHAPS is a nondenaturing zwitterionic detergent for membrane biochemistry.
Useful for solubilizing membrane proteins and breaking protein-protein interactions. CHAPS′ small micellar molecular weight (6,150) and high critical micelle concentration (6-10 mM) allow it to be removed from samples by dialysis. It is also suitable for protein solubilization for isoelectric focusing and two-dimensional electrophoresis. CHAPS is commonly used for non-denaturing (without urea) IEF and has been shown to give excellent resolution of some subcellular preparations and plant proteins. Concentrations between 2-4% (w/v) are typically used in an IEF gel.

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
089H5075
080K5316
069H5230
069H5080
051K5308

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L M Hjelmeland
Proceedings of the National Academy of Sciences of the United States of America, 77(11), 6368-6370 (1980-11-01)
The synthesis and evaluation of a new detergent that is a zwitterionic derivative of cholic acid is presented. This detergent combines the useful properties of both the sulfobetaine-type detergents and the bile salt anions. The new detergent proved to be
Eric M Wexler et al.
Stem cells (Dayton, Ohio), 27(5), 1130-1141 (2009-05-07)
Wnt signaling regulates neural stem cell (NSC) function and development throughout an individual's lifetime. Intriguingly, adult hippocampal progenitors (AHPs) produce several Wnts, and the intracellular machinery necessary to respond to them, creating the potential for an active autocrine-signaling loop within
Ana Paula Catunda Lemos et al.
PloS one, 7(1), e28869-e28869 (2012-01-17)
The neonatal Fc receptor (FcRn) regulates IgG and albumin homeostasis, mediates maternal IgG transport, takes an active role in phagocytosis, and delivers antigen for presentation. We have previously shown that overexpression of FcRn in transgenic mice significantly improves the humoral
Kathrin Schanda et al.
BMC research notes, 4, 6-6 (2011-01-18)
The reticulon Nogo-B participates in cellular and immunological processes in murine macrophages. Since leukocytes are an essential part of the immune system in health and disease, we decided to investigate the expression of Nogo-A, Nogo-B and Nogo-C in different human
Koos Rooijers et al.
BMC genomics, 12, 6-6 (2011-01-07)
Peptide spectrum matching (PSM) is the standard method in shotgun proteomics data analysis. It relies on the availability of an accurate and complete sample proteome that is used to make interpretation of the spectra feasible. Although this procedure has proven
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