C5862
CD30/Fc Chimera human
>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
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About This Item
UNSPSC Code:
12352200
MDL number:
recombinant
expressed in NSO cells
assay
>95% (SDS-PAGE)
form
lyophilized powder
mol wt
100-110 kDa by SDS-PAGE (reducing), calculated mol wt 66 kDa
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... TNFRSF8(943)
General description
The extracellular domain of human CD30/Fc Chimera (amino acids 1-379) is fused to the C-terminal Fc domain of human IgG.
Biochem/physiol Actions
CD30, a type I transmembrane glycoprotein, is a member of the TNF receptor family. CD30 has a crucial role in the pathophysiology of Hodgkin′s disease and other CD30+ lymphomas. The ligand for CD30 is CD30 ligand (CD30L). CD30-CD30L interaction mediates cell proliferation, cell activation, cell differentiation, and cell death.
CD30, a type I transmembrane glycoprotein, is a member of the TNF receptor family; mediates cell proliferation, cell activation, cell differentiation, and cell death.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Analysis Note
The biological activity is measured by its ability to neutralize recombinant human CD30 ligand on HDLM-2 cells, a Hodgkin′s lymphoma cell line.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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