C6085
1-(3-Chlorophenylamino)-4-phenylphthalazine
≥98%
Synonym(s):
MY-5445
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About This Item
Empirical Formula (Hill Notation):
C20H14ClN3
CAS Number:
Molecular Weight:
331.80
UNSPSC Code:
12352204
MDL number:
assay
≥98%
SMILES string
Clc1cccc(Nc2nnc(-c3ccccc3)c4ccccc24)c1
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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I D Duarte et al.
European journal of pharmacology, 217(2-3), 225-227 (1992-07-07)
We tested the hypothesis that activation of the nitric oxide (NO)-cGMP pathway is involved in the mechanism of two directly acting non-opiate peripheral analgesics, myrcene and dipyrone, using our modification of the Randall-Selitto test. The NO inhibitor, NG-monomethyl-L-arginine (50 micrograms/paw)
I D Duarte et al.
Mediators of inflammation, 9(1), 25-30 (2000-07-06)
NG-nitro-L-arginine methyl ester (L-NAME) has been used extensively as a paradigmatic inhibitor of NO synthase and has been shown to cause antinociception in several experimental models. We describe here how L-NAME produced a dose-dependent antinociceptive effect when injected intraperitoneally in
J E Souness et al.
British journal of pharmacology, 98(3), 725-734 (1989-11-01)
1. The mechanism by which M&B 22,948, MY-5445, vinpocetine and 1-methyl-3-isobutyl-8-(methylamino)xanthine (MIMAX), which have been described as selective cyclic GMP phosphodiesterase (PDE) inhibitors, relax rat aorta was investigated. 2. Three cyclic nucleotide PDEs were identified in the soluble fraction of