C6085
1-(3-Chlorophenylamino)-4-phenylphthalazine
≥98%
Synonym(s):
MY-5445
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About This Item
Empirical Formula (Hill Notation):
C20H14ClN3
CAS Number:
Molecular Weight:
331.80
MDL number:
UNSPSC Code:
12352204
Assay
≥98%
SMILES string
Clc1cccc(Nc2nnc(-c3ccccc3)c4ccccc24)c1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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J E Souness et al.
British journal of pharmacology, 98(3), 725-734 (1989-11-01)
1. The mechanism by which M&B 22,948, MY-5445, vinpocetine and 1-methyl-3-isobutyl-8-(methylamino)xanthine (MIMAX), which have been described as selective cyclic GMP phosphodiesterase (PDE) inhibitors, relax rat aorta was investigated. 2. Three cyclic nucleotide PDEs were identified in the soluble fraction of
S H Ferreira et al.
Agents and actions. Supplements, 32, 101-106 (1991-01-01)
We have previously described the peripheral analgesic effect of dibutyryl cyclic GMP, acetylcholine (ACh) and morphine (Mph) injected into the rat paws. Since ACh induces nitric oxide (NO) release from endothelial cells which is though to stimulate guanylate cyclase (GC)
M W Radomski et al.
Biochemical and biophysical research communications, 148(3), 1482-1489 (1987-11-13)
The inhibition of platelet adhesion by nitric oxide (NO) and prostacyclin and their mechanism of action was studied. Platelet adhesion to collagen fibrils and endothelial cell matrix was inhibited completely by NO but only partially by prostacyclin. Adhesion of platelets
I D Duarte et al.
Mediators of inflammation, 9(1), 25-30 (2000-07-06)
NG-nitro-L-arginine methyl ester (L-NAME) has been used extensively as a paradigmatic inhibitor of NO synthase and has been shown to cause antinociception in several experimental models. We describe here how L-NAME produced a dose-dependent antinociceptive effect when injected intraperitoneally in
I D Duarte et al.
European journal of pharmacology, 217(2-3), 225-227 (1992-07-07)
We tested the hypothesis that activation of the nitric oxide (NO)-cGMP pathway is involved in the mechanism of two directly acting non-opiate peripheral analgesics, myrcene and dipyrone, using our modification of the Randall-Selitto test. The NO inhibitor, NG-monomethyl-L-arginine (50 micrograms/paw)
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