C6085
1-(3-Chlorophenylamino)-4-phenylphthalazine
≥98%
Synonym(s):
MY-5445
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About This Item
Empirical Formula (Hill Notation):
C20H14ClN3
CAS Number:
Molecular Weight:
331.80
UNSPSC Code:
12352204
MDL number:
SMILES string
Clc1cccc(Nc2nnc(-c3ccccc3)c4ccccc24)c1
assay
≥98%
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
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I D Duarte et al.
European journal of pharmacology, 221(1), 171-174 (1992-10-06)
The role of the L-arginine-NO-cGMP pathway in morphine-induced central analgesia was investigated in two nociceptive tests: PGE2-induced hind paw hyperalgesia and tail-flick. The central analgesic effect of morphine was potentiated by MY5445, a specific cGMP phosphodiesterase inhibitor. I.c.v. injections of
M Hagiwara et al.
The Journal of pharmacology and experimental therapeutics, 228(2), 467-471 (1984-02-01)
The effects of a novel compound, 1-(3-chloroanilino)-4-phenylphthalazine (MY-5445), on cyclic nucleotide metabolism and in vitro aggregation of human platelets were investigated. The concentrations of MY-5445 producing 50% inhibition of human platelet aggregation induced by 3 microM ADP, 3 micrograms/ml of
N Akamatsu et al.
Journal of neuroendocrinology, 5(5), 517-522 (1993-10-01)
The effects of natriuretic peptides on electrical activity and cellular cGMP levels were studied in neurons of the supraoptic nucleus (SON) of rat hypothalamic slice preparations. Intracellular and extracellular recordings showed that bath application of A type natriuretic peptide (ANP)
E Messina et al.
Nucleosides, nucleotides & nucleic acids, 23(8-9), 1551-1554 (2004-12-02)
We have shown that intracellular cGMP levels increase during retinoic acid- and mycophenolic acid-induced neuroblastoma differentiation and that a 6 days treatment with 1 mM dbcGMP lead LAN5 cell to elaborate a network of neuritic processes suggesting an involvement of
The molecular mechanism of action of peripheral morphine analgesia: stimulation of the cGMP system via nitric oxide release.
S H Ferreira et al.
European journal of pharmacology, 201(1), 121-122 (1991-08-16)
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