C6493
Cyclapolin 9
powder
Synonym(s):
7-Nitro-5-(trifluoromethyl)-2-Benzothiazolecarboxamide 3-oxide
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About This Item
Empirical Formula (Hill Notation):
C9H4F3N3O4S
CAS Number:
Molecular Weight:
307.21
UNSPSC Code:
12352200
MDL number:
SMILES string
NC(=O)c1sc2c(cc(cc2[n+]1[O-])C(F)(F)F)[N+]([O-])=O
assay
≥98% (HPLC)
form
powder
color
yellow
solubility
DMSO: >10 mg/mL, H2O: insoluble 2 mg/mL (Lower concentrations not tested)
storage temp.
2-8°C
Biochem/physiol Actions
Cyclapolin 9 is a Polo-like kinase (Plk) inhibitor. IC50 is 500 nM; selective against a panel of 20 kinases
Polo-like kinase inhibitor
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Campbell McInnes et al.
Nature chemical biology, 2(11), 608-617 (2006-10-10)
Polo-like kinases (Plks) have several functions in mitotic progression and are upregulated in many tumor types. Small-molecule Plk inhibitors would be valuable as tools for studying Plk biology and for developing antitumor agents. Guided by homology modeling of the Plk1
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