C6581
Cyclo(Arg-Gly-Asp-D-Phe-Val)
≥97% (HPLC)
Synonym(s):
cRGDfV
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About This Item
Empirical Formula (Hill Notation):
C26H38N8O7
CAS Number:
Molecular Weight:
574.63
UNSPSC Code:
12352200
MDL number:
assay
≥97% (HPLC)
storage temp.
−20°C
Biochem/physiol Actions
RGD peptides are fibronectin fragments that guide integrin-induced cell attachment, proliferation and migration. Cyclic RGD peptides containing D-Phe, such as cRGDfV, are selective antagonists of ανβ3 and ανβ5 integrins that inhibit the binding of these integrins to vitronectin. cRGDfV inhibits angiogenesis and vascular remodeling. cRGDfV also blocks cellular adhesion and may induce apoptosis in cells bearing surface ανβ3 integrin, although its anti-tumor effect may be primarily due to its antiangiogenic action.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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P C Brooks et al.
Cell, 79(7), 1157-1164 (1994-12-30)
A single intravascular injection of a cyclic peptide or monoclonal antibody antagonist of integrin alpha v beta 3 disrupts ongoing angiogenesis on the chick chorioallantoic membrane (CAM). This leads to the rapid regression of histologically distinct human tumors transplanted onto
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