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Merck
CN

C6637

Cytochalasin A from Drechslera dematioidea

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About This Item

Empirical Formula (Hill Notation):
C29H35NO5
CAS Number:
14110-64-6
Molecular Weight:
477.59
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
24892882
EC Number:
237-964-9
Beilstein/REAXYS Number:
949521
MDL number:
MFCD00005935

Key Documents

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InChI key

ZMAODHOXRBLOQO-TZVKRXPSSA-N

InChI

1S/C29H35NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,23-24,26-27,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,23+,24+,26+,27-,29-/m1/s1

SMILES string

C[C@@H]1CCCC(=O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O

form

powder

storage temp.

−20°C

Quality Level

200

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Biochem/physiol Actions

Cytochalasin A reacts with sulfhydryls, and inhibits growth and glucose transport in Saccharomyces.
Cytochalasin A reacts with sulfhydryls, and inhibits growth and glucose transport in Saccharomyces. Cytochalasin A is an oxidizing analog of cytochalsin B.

Other Notes

Oxidized analog of cytochalasin B.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Repr. 2

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

高风险级别生物产品--毒素类产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000234989
0000225724
0000234989
0000225724
0000142848

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J Adrian Lunn et al.
The Journal of biological chemistry, 282(14), 10370-10379 (2007-02-10)
The results presented here demonstrate that focal adhesion kinase (FAK) Tyr-861 is the predominant tyrosine phosphorylation site stimulated by hyperosmotic stress in a variety of cell types, including epithelial cell lines (ileum-derived IEC-18, colon-derived Caco2, and stomach-derived NCI-N87), FAK null
M Riquelme et al.
Protoplasma, 222(3-4), 211-215 (2004-01-10)
It is well established that cytoplasmic microtubules are depolymerized during nuclear division and reassembled as mitotic microtubules. Mounting evidence showing that cytoplasmic microtubules were also involved in apical growth of fungal hyphae posed the question of whether apical growth became
Gladys Corrêa et al.
Parasitology research, 98(3), 250-256 (2005-12-14)
Giardia lamblia, a flagellated protist, is the parasite most commonly found in the intestinal tract of humans and other mammals causing a disease known as giardiasis. This parasite presents several cytoskeletal structures whose major components are microtubules, namely: the ventral
I I Pelevina et al.
Radiatsionnaia biologiia, radioecologiia, 49(4), 419-424 (2009-10-06)
On the blood lymphocytes of prostate cancer (PCa) patients before and during radiotherapy: DNA damage by DNA commet assay (DNA double strand breaks - DSB); the frequency of cells with micronuclei (MN) with cytokinetic cytochalasin block; the adaptive response induction
Tiago dos Santos et al.
PloS one, 6(9), e24438-e24438 (2011-09-29)
Nanotechnology is expected to play a vital role in the rapidly developing field of nanomedicine, creating innovative solutions and therapies for currently untreatable diseases, and providing new tools for various biomedical applications, such as drug delivery and gene therapy. In
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