C6760
Cytosine β-D-arabinofuranoside 5′-monophosphate
≥99%
Synonym(s):
Ara-CMP
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About This Item
Empirical Formula (Hill Notation):
C9H14N3O8P
CAS Number:
Molecular Weight:
323.20
UNSPSC Code:
41106305
PubChem Substance ID:
MDL number:
assay
≥99%
form
solid
storage temp.
−20°C
SMILES string
NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]2O
InChI
1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7+,8-/m1/s1
InChI key
IERHLVCPSMICTF-CCXZUQQUSA-N
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E M McIntosh et al.
Current genetics, 10(8), 579-585 (1986-01-01)
Cytosine arabinoside (araC), a potent inhibitor of DNA replication in mammalian cells, was found to be completely ineffective in Saccharomyces cerevisiae. The 5' monophosphate derivative, araCMP, is toxic and effectively inhibits both nuclear and mitochondrial DNA synthesis in this organism.
D D Ross et al.
Cancer research, 50(9), 2658-2666 (1990-05-01)
The pH-step alkaline elution method enables the isolation and quantification of nascent DNA (nDNA) replication intermediates, including Okazaki fragments, short length nDNA from replicon origins, longer lengths of nascent but subgenomic length nDNA (molecular weight, 20-30 x 10(6)), and full
F W Perrino et al.
The Journal of biological chemistry, 267(32), 23043-23051 (1992-11-15)
The incorporation of cytosine arabinoside monophosphate (araCMP) into DNA at internucleotide linkages by DNA polymerase alpha (DNA pol alpha) has been investigated by using oligonucleotide primed DNA templates. The products of reactions catalyzed by DNA pol alpha in vitro were