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Merck
CN

C7270

Cefamandole nafate

~95%

Synonym(s):

Cefamandole formate sodium salt

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About This Item

Linear Formula:
C19H17N6O6S2Na
CAS Number:
42540-40-9
Molecular Weight:
512.49
UNSPSC Code:
51101500
PubChem Substance ID:
24892951
EC Number:
255-877-4
MDL number:
MFCD00864877

Key Documents

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InChI key

ICZOIXFFVKYXOM-YCLOEFEOSA-M

InChI

1S/C19H18N6O6S2.Na/c1-24-19(21-22-23-24)33-8-11-7-32-17-12(16(28)25(17)13(11)18(29)30)20-15(27)14(31-9-26)10-5-3-2-4-6-10;/h2-6,9,12,14,17H,7-8H2,1H3,(H,20,27)(H,29,30);/q;+1/p-1/t12-,14-,17-;/m1./s1

SMILES string

[Na+].Cn1nnnc1SCC2=C(N3C(SC2)[C@H](NC(=O)[C@H](OC=O)c4ccccc4)C3=O)C([O-])=O

assay

~95%

mode of action

cell wall synthesis | interferes

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General description

Chemical structure: β-lactam

Application

Cefamandole is used to study the effects of expression and inhibition of PBP 2A and other penicillin-binding proteins (PDPs) on bacterial cell wall mucopeptide synthesis.

Biochem/physiol Actions

Cefamandole nafate inhibits bacterial cell wall synthesis by inhibiting PBP 2A and other penicillin-binding proteins. Cefamandole nafate has been shown to be rapidly converted to cefamandolein bacteriological media .

Physical form

sodium carbonate: approx. 5%

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
029K0560
048K0509
067K0497
067K0496
076K0613

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D H Livingston et al.
Surgery, gynecology & obstetrics, 168(2), 138-142 (1989-02-01)
Hemorrhagic shock has been associated with an increased risk of infection after injury. The immediate and long term effects of hemorrhagic shock without tissue injury on the susceptibility of an animal to infection and the efficacy of antibiotic prophylaxis to
L F Harris et al.
Postgraduate medicine, 76(6), 71-72 (1984-11-01)
Mycoplasma pneumoniae is one of the most common causes of community-acquired pneumonia. Infection is usually self-limited, but fulminant pneumonia and extrapulmonary complications can supervene. Usually, unilateral confluent, patchy, or nodular infiltrates of the lower lobe are seen on roentgenograms. Diagnosis
Adult linear IgA disease associated with an erythema multiforme-like drug reaction.
Z B Argenyi et al.
Cleveland Clinic journal of medicine, 54(5), 445-450 (1987-09-01)
R Gonen et al.
Obstetrics and gynecology, 67(4), 545-548 (1986-04-01)
The efficacy of intraoperative irrigation with cefamandole nafate at cesarean section was evaluated in a prospective, randomized double-blind study. Two hundred and eight patients were treated with antibiotic irrigation and intravenous placebo or with perioperative intravenous cefamandole and irrigated with
M B Henley et al.
Clinical orthopaedics and related research, (209)(209), 249-254 (1986-08-01)
A prospective, randomized, double-blind study was conducted to determine the efficacy of cefamandole nafate in reducing infections in general orthopedic procedures. Of 743 patients initially entered into the study, 715 (362 on cefamandole, 353 on placebo) fulfilled the requirements of
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