C7420
μ-Conotoxin GIIIA
≥90% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C100H170N38O32S6
CAS Number:
Molecular Weight:
2609.05
UNSPSC Code:
12352200
assay
≥90% (HPLC)
form
powder
composition
Peptide content, ~60%
storage temp.
−20°C
Biochem/physiol Actions
Selective blocker of voltage-dependent Na+ channels which exhibits channel binding kinetics similar to those of tetrodotoxin and saxitoxin, but possesses a >1,000 fold selectivity for muscle versus neuronal Na+ channels; originally isolated from the venom of the marine snail Conus geographus L.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
高风险级别生物产品--毒素类产品
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F A Meunier et al.
British journal of pharmacology, 121(6), 1224-1230 (1997-07-01)
1. The actions of a chromatographically identified extract of the marine dinoflagellate Ostreopsis lenticularis, named ostreotoxin-3 (OTX-3), were studied on frog isolated neuromuscular preparations. 2. OTX-3 (1-10 microg ml(-1)) applied to cutaneous pectoris nerve-muscle preparations depolarized skeletal muscle fibres and
J A Grimes et al.
Journal of cellular physiology, 175(1), 50-58 (1998-03-10)
Voltage-gated Na+ channels, classically associated with impulse conduction in excitable tissues, are also found in a variety of epithelial cell types where their possible functions are not known so well. We have previously reported expression of a voltage-gated Na+ channel
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