C7499
CK-548
≥98% (HPLC)
Synonym(s):
2-(3-Bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-4-thiazolidinone, CK-0993548
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About This Item
Empirical Formula (Hill Notation):
C15H11BrClNO2S
CAS Number:
Molecular Weight:
384.68
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
solubility
DMSO: 24 mg/mL
storage temp.
2-8°C
SMILES string
Oc1ccc(Cl)cc1N2C(SCC2=O)c3cccc(Br)c3
InChI
1S/C15H11BrClNO2S/c16-10-3-1-2-9(6-10)15-18(14(20)8-21-15)12-7-11(17)4-5-13(12)19/h1-7,15,19H,8H2
InChI key
KEGQNJITMFBVAC-UHFFFAOYSA-N
Biochem/physiol Actions
CK-548 inhibits the activity of actin-related protein (Arp)2/3 complex by inserting into the hydrophobic core of Arp3 and altering its conformation.
CK-548 inhibits the activity of actin-related protein (Arp)2/3 complex by inserting into the hydrophobic core of Arp3 and altering its conformation: inhibits
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Renu Khasa et al.
Microbial pathogenesis, 149, 104565-104565 (2020-10-16)
Multiple membrane trafficking networks operate in the eukaryotic cell and are hijacked by viruses to establish infection. Recent studied have highlighted that viruses can exploit distinct pathways depending on the cell type. Japanese encephalitis virus (JEV), a neurotropic flavivirus, can
Arnat Balabiyev et al.
Molecular biology of the cell, 31(18), 2002-2020 (2020-06-25)
Macrophage fusion resulting in the formation of multinucleated giant cells (MGCs) is a multistage process that requires many adhesion-dependent steps and involves the rearrangement of the actin cytoskeleton. The diversity of actin-based structures and their role in macrophage fusion is
Renu Khasa et al.
The Journal of general virology, 100(2), 176-186 (2018-11-30)
Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, is one of the leading global causes of virus-induced encephalitis. The infectious life-cycle of viruses is heavily dependent on the host membrane trafficking network. Here, we have performed a RNA-interference-based screen using a
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C7499-5MG | 04061833218136 |