C7597
Anti-Chloride Channel-K (CLC-K) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
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About This Item
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
rat
technique(s)
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot (chemiluminescent): 1:200
UniProt accession no.
storage temp.
−20°C
General description
The gene Chloride channel Kb (CLCNKB) is mapped to human chromosome 1p36. It is a kidney specific protein and is present in basolateral membranes of renal tubules.
Immunogen
synthetic peptide corresponding to amino acids 674-687 of rat longer form CLC-K2L (with additional C-terminal cysteine). The epitope sequence corresponds to the CLC-K2 isotype. It differs by only one residue from rat CLC-K1, or from corresponding human or mouse CLC-Ka or CLC-Kb.
Application
Anti-Chloride Channel-K (CLC-K) antibody produced in rabbit is suitable for the following applications:
- Immunohistochemistry
- Immunoprecipitation
- Western blotting (chemiluminescent) at a dilution of 1:200
Biochem/physiol Actions
Mutations in chloride channel Kb (CLCNKB) gene cause Bartter syndrome (is a salt-losing renal tubulopathy) and is associated with hypertension (EH). Two classes of CLCNKB mutants are distinguished namely, nonconducting mutants associated with low total protein expression and partially conducting mutants with unaltered channel properties and ClC-Kb protein abundance.
Physical form
Lyophilized at ~0.6 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose, and 0.025% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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