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Merck
CN

C7866

CGP-53353

solid

Synonym(s):

5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione, DAPH 2

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About This Item

Empirical Formula (Hill Notation):
C20H13F2N3O2
CAS Number:
145915-60-2
Molecular Weight:
365.33
NACRES:
NA.77
PubChem Substance ID:
24892990
UNSPSC Code:
12352200
MDL number:
MFCD00938569

Key Documents

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InChI

1S/C20H13F2N3O2/c21-11-1-5-13(6-2-11)23-17-9-15-16(20(27)25-19(15)26)10-18(17)24-14-7-3-12(22)4-8-14/h1-10,23-24H,(H,25,26,27)

SMILES string

Fc1ccc(Nc2cc3C(=O)NC(=O)c3cc2Nc4ccc(F)cc4)cc1

InChI key

RONQPWQYDRPRGG-UHFFFAOYSA-N

biological source

synthetic (organic)

assay

≥98% (HPLC)

form

solid

color

orange

solubility

DMSO: >10 mg/mL, H2O: insoluble

storage temp.

2-8°C

Gene Information

human ... EGFR(1956)

Biochem/physiol Actions

Selective PKCβII inhibitor. IC50 - 410 nM for PKCβII vs 3.8 μM for PKCβI. Inhibits nPKCs and aPKCs only above 22 μM and other kinases such as protein kinase A, casein kinase I and II, c-src kinase, c-lyn kinase, c-fgr kinase, and v-abl kinase at an IC50 of greater than 50 μM.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
075M4713V
126K46063
126K46062
126K46061
126K4606

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