C7866
CGP-53353
solid
Synonym(s):
5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione, DAPH 2
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About This Item
Empirical Formula (Hill Notation):
C20H13F2N3O2
CAS Number:
Molecular Weight:
365.33
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
biological source
synthetic (organic)
Assay
≥98% (HPLC)
form
solid
color
orange
solubility
DMSO: >10 mg/mL
H2O: insoluble
storage temp.
2-8°C
SMILES string
Fc1ccc(Nc2cc3C(=O)NC(=O)c3cc2Nc4ccc(F)cc4)cc1
InChI
1S/C20H13F2N3O2/c21-11-1-5-13(6-2-11)23-17-9-15-16(20(27)25-19(15)26)10-18(17)24-14-7-3-12(22)4-8-14/h1-10,23-24H,(H,25,26,27)
InChI key
RONQPWQYDRPRGG-UHFFFAOYSA-N
Gene Information
human ... EGFR(1956)
Biochem/physiol Actions
Selective PKCβII inhibitor. IC50 - 410 nM for PKCβII vs 3.8 μM for PKCβI. Inhibits nPKCs and aPKCs only above 22 μM and other kinases such as protein kinase A, casein kinase I and II, c-src kinase, c-lyn kinase, c-fgr kinase, and v-abl kinase at an IC50 of greater than 50 μM.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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