C7911
Concanavalin A from Canavalia ensiformis (Jack bean)
agarose conjugate, Type III-ASCL, saline suspension
Synonym(s):
Con A
conjugate
agarose conjugate
type
Type III-ASCL
form
saline suspension
extent of labeling
~10 mg per mL
matrix
4% cross-linked beaded agarose
matrix activation
cyanogen bromide
matrix attachment
amino
matrix spacer
1 atom
capacity
~10 mg/mL binding capacity (peroxidase (P 8375))(pH 6.0)
~6 mg/mL binding capacity (yeast mannan)(pH 7.2)
storage temp.
2-8°C
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Biochem/physiol Actions
Con A is not blood group specific but has an affinity for terminal α-D-mannosyl and α-D-glucosyl residues. Ca2+ and Mn2+ ions are required for activity. Con A dissociates into dimers at pH 5.6 or below. Between pH 5.8 and pH 7.0, Con A exists as a tetramer; above pH 7.0 higher aggregates are formed. Con A exhibits mitogenic activity which is dependent on its degree of aggregation. Succinylation results in an active dimeric form which remains a dimer above pH 5.6.
Physical form
Suspension in 1.0 M NaCl containing 1 mM CaCl2, 1 mM MgCl2, 1 mM MnCl2 and 0.02% thimerosal
Preparation Note
One mL suspension yields approx. 0.5 ml gel.
Analysis Note
Where reported, agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 6.8, containing Ca2+ and Mn2+ of a 1 mg per mL solution. This activity is the lowest concentration to agglutinate a 2% suspension of human erythrocytes after 1 hr incubation at 25 °C.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Mariam Al-Shamsi et al.
BMC gastroenterology, 13, 6-6 (2013-01-15)
A novel in vitro system was employed to investigate liver tissue respiration (mitochondrial O2 consumption) in mice treated with concanavalin A (Con A). This study aimed to investigate hepatocyte bioenergetics in this well-studied hepatitis model. C57Bl/6 and C57Bl/6 IFN-γ-/- mice
Tamara Potikha et al.
Hepatology (Baltimore, Md.), 58(1), 192-204 (2013-02-21)
Chronic inflammation is strongly associated with an increased risk for hepatocellular carcinoma (HCC) development. The multidrug resistance 2 (Mdr2)-knockout (KO) mouse (adenosine triphosphate-binding cassette b4(-/-) ), a model of inflammation-mediated HCC, develops chronic cholestatic hepatitis at an early age and
Ze Tao et al.
Developmental and comparative immunology, 40(1), 69-77 (2013-01-29)
Recent studies have found that, in addition to hematopoiesis, granulocyte-macrophage colony-stimulating factor (GMCSF) plays pivotal roles in multiple immune disorders. The gene encoding Macaca mulatta GMCSF (mmGMCSF) was cloned from stimulated peripheral blood mononuclear cells (PBMCs). Concanavalin A (Con A)
Z Guo et al.
Journal of fish biology, 82(1), 189-205 (2013-01-22)
The full-length complementary DNA (cDNA) sequences encoding cd8α and cd8β molecules were sequenced and characterized from mandarin fish Siniperca chuatsi. Conserved motifs and residues were found to be present in derived peptides of the Cd8 molecules. For example, WXR motif
In-Jae Park et al.
Poultry science, 92(2), 352-357 (2013-01-10)
We evaluated the immunomodulatory effects of a proanthocyanidin-rich extract (PAE) from Pinus radiata bark in Korean native chickens. In experiment 1, proliferation of peripheral blood mononuclear cells was significantly enhanced in chickens administered 1.25, 2.5, 5, and 10 mg/kg of
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